Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia

Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults; however, the genetic aetiology of the disease is not yet fully understood. A quantitative expression profile analysis of 157 mature miRNAs was performed on 100 AML patients representing the spectrum of known karyotypes commo...

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Veröffentlicht in:	PloS one 2008-05, Vol.3 (5), p.e2141-e2141
Hauptverfasser:	Dixon-McIver, Amanda, East, Phil, Mein, Charles A, Cazier, Jean-Baptiste, Molloy, Gael, Chaplin, Tracy, Andrew Lister, T, Young, Bryan D, Debernardi, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Adults Analysis of Variance Apoptosis Base Sequence Bioinformatics Biology Bone marrow Bone marrow transplantation Cancer Cell Biology/Gene Expression Cell growth Chromosome Aberrations Chromosomes, Human, Pair 14 Cluster analysis Cryopreservation Deregulation DNA Probes Fluorescence Gene expression Gene Expression Profiling Gene fusion Gene regulation Genes Genetics and Genomics/Cancer Genetics Genetics and Genomics/Gene Expression Genetics and Genomics/Genetics of Disease Genomes Humans In Situ Hybridization, Fluorescence Karyotypes Karyotyping Leukemia Leukemia, Myeloid, Acute - genetics Medical research Medicine MicroRNA MicroRNAs MicroRNAs - genetics miRNA Morphology Neuroblastoma Oligonucleotides - chemistry Oncology Oncology/Hematological Malignancies Pancreatic cancer Polymerase Chain Reaction Ribonucleic acid RNA Studies Translocation Tumors Variance analysis
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