Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex

Escherichia coli strains adhere to the normally sterile human uroepithelium using type 1 pili, that are long, hairy surface organelles exposing a mannose-binding FimH adhesin at the tip. A small percentage of adhered bacteria can successfully invade bladder cells, presumably via pathways mediated by...

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Veröffentlicht in:	PloS one 2008-04, Vol.3 (4), p.e2040
Hauptverfasser:	Wellens, Adinda, Garofalo, Corinne, Nguyen, Hien, Van Gerven, Nani, Slättegård, Rikard, Hernalsteens, Jean-Pierre, Wyns, Lode, Oscarson, Stefan, De Greve, Henri, Hultgren, Scott, Bouckaert, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Escherichia coli - chemistry Adhesins, Escherichia coli - metabolism Adhesion Adhesive bonding Animals Antagonists Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Aromatic compounds Asparagine - metabolism Automation Bacteria Bacterial Adhesion - drug effects Binding sites Biochemistry Biochemistry/Biomacromolecule-Ligand Interactions Biochemistry/Biomimetic Chemistry Biochemistry/Drug Discovery Biofilms Biofilms - drug effects Biophysics/Biomacromolecule-Ligand Interactions Bladder Blocking Catheterization Cell Biology/Cell Adhesion Cell Biology/Microbial Growth and Development Cell Line Chemical Biology/Biomimetic Chemistry Crystal structure Crystallography Crystallography, X-Ray Cystitis Cystitis - microbiology Disaccharides - metabolism Disease Models, Animal E coli Epitopes Escherichia coli Escherichia coli - chemistry Escherichia coli - drug effects Escherichia coli - physiology Fimbriae Proteins - chemistry Fimbriae Proteins - metabolism Fimbriae, Bacterial - drug effects Fluxing Glycosylation - drug effects Health aspects Humans Infectious Diseases/Bacterial Infections Infectious Diseases/Urological Infections Inhibitors Integrins Intracellular Space - drug effects Intracellular Space - metabolism Mannose Mannosides - metabolism Mice Microbiology/Immunity to Infections Mimicry Monosaccharides Oligosaccharides - chemistry Organelles Pili Protein Structure, Tertiary Proteins Receptors, Cell Surface - metabolism Recurrent infection Substrate Specificity - drug effects Urinary bladder Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - drug therapy Urogenital system Urology/Urological Infections
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