Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma

While neurosphere- as well as xenograft tumor-initiating cells have been identified in gliomas, the resemblance between glioma cells and neural stem/progenitor cells as well as the prognostic value of stem/progenitor cell marker expression in glioma are poorly clarified. Viable glioma cells were cha...

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Veröffentlicht in:	PloS one 2008-04, Vol.3 (4), p.e1936-e1936
Hauptverfasser:	Rebetz, Johan, Tian, Dongping, Persson, Annette, Widegren, Bengt, Salford, Leif G, Englund, Elisabet, Gisselsson, David, Fan, Xiaolong
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Analysis Antigens, CD - biosynthesis Basic Medicine Biomarkers Blockage Brain cancer Brain Neoplasms - metabolism Brain tumors CD44 antigen CD45 antigen Cell Biology/Gene Expression Cell Differentiation Cell Lineage Cell survival Cells (biology) Chromosomes Clinical Medicine Differentiation Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Glial fibrillary acidic protein Glial stem cells Glioma Glioma - diagnosis Glioma - metabolism Glioma - pathology Glioma cells Gliomas Glycoproteins - biosynthesis Growth factors Humans Intermediate filament proteins Karyotypes Karyotyping Kirurgi Klinisk medicin Laboratories Medical and Health Sciences Medical Genetics Medical prognosis Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Multiple sclerosis Neural stem cells Neuroglia - cytology Neuroglia - metabolism Neurologi Neurology Neuronal-glial interactions Neurons Neurons - metabolism Neurons - pathology Neurosurgery Oncology/Neuro-Oncology Peptides Phenotype Phosphopyruvate hydratase Progenitor cells Prognosis Stem cells Stem Cells - cytology Studies Surface markers Surgery Synaptophysin Tumors Xenografts
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