Heat resistance mediated by a new plasmid encoded Clp ATPase, ClpK, as a possible novel mechanism for nosocomial persistence of Klebsiella pneumoniae

Klebsiella pneumoniae is an important opportunistic pathogen and a frequent cause of nosocomial infections. We have characterized a K. pneumoniae strain responsible for a series of critical infections in an intensive care unit over a two-year period. The strain was found to be remarkably thermotoler...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e15467-e15467
Hauptverfasser:	Bojer, Martin Saxtorph, Struve, Carsten, Ingmer, Hanne, Hansen, Dennis Schrøder, Krogfelt, Karen Angeliki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adaptation, Physiological - genetics Adenosine triphosphatase Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Amino acids Aspergillus nidulans ATPases Bacterial Proteins - genetics Bacterial Proteins - metabolism Biology Cloning Cross infection Cross Infection - enzymology Cross Infection - genetics Cross Infection - microbiology E coli Escherichia coli Fitness Genes Genotype & phenotype Health aspects Heat resistance Heat shock Hot Temperature Humans Intensive care Klebsiella Klebsiella Infections - enzymology Klebsiella Infections - genetics Klebsiella pneumoniae Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Medicine Mutation Nosocomial infection Nosocomial infections Opportunist infection Plasmids Plasmids - genetics Pneumonia Proteins Reproductive fitness Salmonella Salmonella Typhimurium Sepsis Shock resistance Surveillance Thermal resistance Thermal stress Transposons Urogenital system
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