Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity

Signal transducers and activators of transcription (STATs) are critical components of cytokine signaling pathways. STAT5A and STAT5B (STAT5), the most promiscuous members of this family, are highly expressed in specific populations of hypothalamic neurons in regions known to mediate the actions of c...

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Veröffentlicht in:	PloS one 2008-02, Vol.3 (2), p.e1639-e1639
Hauptverfasser:	Lee, Ji-Yeon, Muenzberg, Heike, Gavrilova, Oksana, Reed, Jacquelyn A, Berryman, Darlene, Villanueva, Eneida C, Louis, Gwendolyn W, Leinninger, Gina M, Bertuzzi, Stefano, Seeley, Randy J, Robinson, Gertraud W, Myers, Martin G, Hennighausen, Lothar
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Adipocytes Animals Body fat Cell Biology/Cell Signaling Cell growth Central nervous system Central Nervous System - metabolism Cerebrospinal fluid Cre recombinase Critical components Cytokines Cytokines - physiology Developmental Biology Diabetes Diabetes and Endocrinology/Obesity Energy balance Energy Metabolism Female Females Food intake Genetics and Genomics/Animal Genetics Granulocyte-macrophage colony-stimulating factor Homeostasis Hyperphagia Hypothalamus Hypothalamus - cytology Insulin Insulin resistance Kidney diseases Kinases Laboratories Low temperature resistance Male Males Medicine Metabolism Mice Mice, Transgenic Nervous system Neurons Neurons - metabolism Obesity Obesity - etiology Physiology Pituitary Pituitary gland Pituitary Gland - metabolism Recombination Rodents Signal Transduction Stat5 protein STAT5 Transcription Factor - physiology Transcription Transcription factors Transducers
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