Chemokine (C-C motif) ligand 2 (CCL2) in sera of patients with type 1 diabetes and diabetic complications
Chemokine (C-C motif) ligand 2 (CCL2), commonly known as monocyte chemoattractant protein-1 (MCP-1), has been implicated in the pathogenesis of many diseases characterized by monocytic infiltration. However, limited data have been reported on MCP-1 in type 1 diabetes (T1D) and the findings are incon...
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| description | Chemokine (C-C motif) ligand 2 (CCL2), commonly known as monocyte chemoattractant protein-1 (MCP-1), has been implicated in the pathogenesis of many diseases characterized by monocytic infiltration. However, limited data have been reported on MCP-1 in type 1 diabetes (T1D) and the findings are inconclusive and inconsistent.
In this study, MCP-1 was measured in the sera from 2,472 T1D patients and 2,654 healthy controls using a Luminex assay. The rs1024611 SNP in the promoter region of MCP-1 was genotyped for a subset of subjects (1764 T1D patients and 1323 controls) using the TaqMan-assay.
Subject age, sex or genotypes of MCP-1 rs1024611SNP did not have a major impact on serum MCP-1 levels in either healthy controls or patients. While hemoglobin A1c levels did not have a major influence on serum MCP-1 levels, the mean serum MCP-1 levels are significantly higher in patients with multiple complications (mean = 242 ng/ml) compared to patients without any complications (mean = 201 ng/ml) (p = 3.5×10(-6)). Furthermore, mean serum MCP-1 is higher in controls (mean = 261 ng/ml) than T1D patients (mean = 208 ng/ml) (p99(th) percentile of patients or 955 ng/ml) of serum MCP-1 is significantly lower in the T1D group compared to the control group (odds ratio = 0.11, p |
| doi_str_mv | 10.1371/journal.pone.0017822 |
| format | Article |
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In this study, MCP-1 was measured in the sera from 2,472 T1D patients and 2,654 healthy controls using a Luminex assay. The rs1024611 SNP in the promoter region of MCP-1 was genotyped for a subset of subjects (1764 T1D patients and 1323 controls) using the TaqMan-assay.
Subject age, sex or genotypes of MCP-1 rs1024611SNP did not have a major impact on serum MCP-1 levels in either healthy controls or patients. While hemoglobin A1c levels did not have a major influence on serum MCP-1 levels, the mean serum MCP-1 levels are significantly higher in patients with multiple complications (mean = 242 ng/ml) compared to patients without any complications (mean = 201 ng/ml) (p = 3.5×10(-6)). Furthermore, mean serum MCP-1 is higher in controls (mean = 261 ng/ml) than T1D patients (mean = 208 ng/ml) (p<10(-23)). More importantly, the frequency of subjects with extremely high levels (>99(th) percentile of patients or 955 ng/ml) of serum MCP-1 is significantly lower in the T1D group compared to the control group (odds ratio = 0.11, p<10(-33)).
MCP-1 may have a dual role in T1D and its complications. While very high levels of serum MCP-1 may be protective against the development of T1D, complications are associated with higher serum MCP-1 levels within the T1D group.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0017822</identifier><identifier>PMID: 21532752</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Autoimmune diseases ; Biology ; Biotechnology ; Cardiovascular disease ; Case-Control Studies ; Chemokine CCL2 - blood ; Chemokine CCL2 - genetics ; Chemokines ; Complications ; Coronary vessels ; Cytokines ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Females ; Gene expression ; Genotype ; Genotypes ; Glucose ; Hemoglobin ; Humans ; Immunology ; Infiltration ; Insulin ; Ligands ; Males ; Medicine ; Middle age ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Mortality ; Pathogenesis ; Patients ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Proteins ; Rheumatoid arthritis ; Rodents ; Veterinary colleges ; Veterinary medicine</subject><ispartof>PloS one, 2011-04, Vol.6 (4), p.e17822-e17822</ispartof><rights>2011 Guan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Guan et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-ea60bcb03b0a35e92d24872b6b656172de0f3cbebe5d0fef00813418e6043da23</citedby><cites>FETCH-LOGICAL-c525t-ea60bcb03b0a35e92d24872b6b656172de0f3cbebe5d0fef00813418e6043da23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075244/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075244/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21532752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Maedler, Kathrin</contributor><creatorcontrib>Guan, Ruili</creatorcontrib><creatorcontrib>Purohit, Sharad</creatorcontrib><creatorcontrib>Wang, Hongjie</creatorcontrib><creatorcontrib>Bode, Bruce</creatorcontrib><creatorcontrib>Reed, John Chip</creatorcontrib><creatorcontrib>Steed, R Dennis</creatorcontrib><creatorcontrib>Anderson, Stephen W</creatorcontrib><creatorcontrib>Steed, Leigh</creatorcontrib><creatorcontrib>Hopkins, Diane</creatorcontrib><creatorcontrib>Xia, Chun</creatorcontrib><creatorcontrib>She, Jin-Xiong</creatorcontrib><title>Chemokine (C-C motif) ligand 2 (CCL2) in sera of patients with type 1 diabetes and diabetic complications</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chemokine (C-C motif) ligand 2 (CCL2), commonly known as monocyte chemoattractant protein-1 (MCP-1), has been implicated in the pathogenesis of many diseases characterized by monocytic infiltration. However, limited data have been reported on MCP-1 in type 1 diabetes (T1D) and the findings are inconclusive and inconsistent.
In this study, MCP-1 was measured in the sera from 2,472 T1D patients and 2,654 healthy controls using a Luminex assay. The rs1024611 SNP in the promoter region of MCP-1 was genotyped for a subset of subjects (1764 T1D patients and 1323 controls) using the TaqMan-assay.
Subject age, sex or genotypes of MCP-1 rs1024611SNP did not have a major impact on serum MCP-1 levels in either healthy controls or patients. While hemoglobin A1c levels did not have a major influence on serum MCP-1 levels, the mean serum MCP-1 levels are significantly higher in patients with multiple complications (mean = 242 ng/ml) compared to patients without any complications (mean = 201 ng/ml) (p = 3.5×10(-6)). Furthermore, mean serum MCP-1 is higher in controls (mean = 261 ng/ml) than T1D patients (mean = 208 ng/ml) (p<10(-23)). More importantly, the frequency of subjects with extremely high levels (>99(th) percentile of patients or 955 ng/ml) of serum MCP-1 is significantly lower in the T1D group compared to the control group (odds ratio = 0.11, p<10(-33)).
MCP-1 may have a dual role in T1D and its complications. While very high levels of serum MCP-1 may be protective against the development of T1D, complications are associated with higher serum MCP-1 levels within the T1D group.</description><subject>Autoimmune diseases</subject><subject>Biology</subject><subject>Biotechnology</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Chemokine CCL2 - blood</subject><subject>Chemokine CCL2 - genetics</subject><subject>Chemokines</subject><subject>Complications</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Females</subject><subject>Gene expression</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Glucose</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infiltration</subject><subject>Insulin</subject><subject>Ligands</subject><subject>Males</subject><subject>Medicine</subject><subject>Middle age</subject><subject>Monocyte chemoattractant protein</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>Mortality</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Rheumatoid arthritis</subject><subject>Rodents</subject><subject>Veterinary colleges</subject><subject>Veterinary 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(C-C motif) ligand 2 (CCL2) in sera of patients with type 1 diabetes and diabetic complications</title><author>Guan, Ruili ; Purohit, Sharad ; Wang, Hongjie ; Bode, Bruce ; Reed, John Chip ; Steed, R Dennis ; Anderson, Stephen W ; Steed, Leigh ; Hopkins, Diane ; Xia, Chun ; She, Jin-Xiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-ea60bcb03b0a35e92d24872b6b656172de0f3cbebe5d0fef00813418e6043da23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Autoimmune diseases</topic><topic>Biology</topic><topic>Biotechnology</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Chemokine CCL2 - blood</topic><topic>Chemokine CCL2 - genetics</topic><topic>Chemokines</topic><topic>Complications</topic><topic>Coronary vessels</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Females</topic><topic>Gene expression</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Glucose</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infiltration</topic><topic>Insulin</topic><topic>Ligands</topic><topic>Males</topic><topic>Medicine</topic><topic>Middle age</topic><topic>Monocyte chemoattractant protein</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Monocytes</topic><topic>Mortality</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Proteins</topic><topic>Rheumatoid arthritis</topic><topic>Rodents</topic><topic>Veterinary colleges</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guan, Ruili</au><au>Purohit, Sharad</au><au>Wang, Hongjie</au><au>Bode, Bruce</au><au>Reed, John Chip</au><au>Steed, R Dennis</au><au>Anderson, Stephen W</au><au>Steed, Leigh</au><au>Hopkins, Diane</au><au>Xia, Chun</au><au>She, Jin-Xiong</au><au>Maedler, Kathrin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemokine (C-C motif) ligand 2 (CCL2) in sera of patients with type 1 diabetes and diabetic complications</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-04-12</date><risdate>2011</risdate><volume>6</volume><issue>4</issue><spage>e17822</spage><epage>e17822</epage><pages>e17822-e17822</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chemokine (C-C motif) ligand 2 (CCL2), commonly known as monocyte chemoattractant protein-1 (MCP-1), has been implicated in the pathogenesis of many diseases characterized by monocytic infiltration. However, limited data have been reported on MCP-1 in type 1 diabetes (T1D) and the findings are inconclusive and inconsistent.
In this study, MCP-1 was measured in the sera from 2,472 T1D patients and 2,654 healthy controls using a Luminex assay. The rs1024611 SNP in the promoter region of MCP-1 was genotyped for a subset of subjects (1764 T1D patients and 1323 controls) using the TaqMan-assay.
Subject age, sex or genotypes of MCP-1 rs1024611SNP did not have a major impact on serum MCP-1 levels in either healthy controls or patients. While hemoglobin A1c levels did not have a major influence on serum MCP-1 levels, the mean serum MCP-1 levels are significantly higher in patients with multiple complications (mean = 242 ng/ml) compared to patients without any complications (mean = 201 ng/ml) (p = 3.5×10(-6)). Furthermore, mean serum MCP-1 is higher in controls (mean = 261 ng/ml) than T1D patients (mean = 208 ng/ml) (p<10(-23)). More importantly, the frequency of subjects with extremely high levels (>99(th) percentile of patients or 955 ng/ml) of serum MCP-1 is significantly lower in the T1D group compared to the control group (odds ratio = 0.11, p<10(-33)).
MCP-1 may have a dual role in T1D and its complications. While very high levels of serum MCP-1 may be protective against the development of T1D, complications are associated with higher serum MCP-1 levels within the T1D group.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21532752</pmid><doi>10.1371/journal.pone.0017822</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Autoimmune diseases Biology Biotechnology Cardiovascular disease Case-Control Studies Chemokine CCL2 - blood Chemokine CCL2 - genetics Chemokines Complications Coronary vessels Cytokines Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Females Gene expression Genotype Genotypes Glucose Hemoglobin Humans Immunology Infiltration Insulin Ligands Males Medicine Middle age Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Mortality Pathogenesis Patients Polymerase Chain Reaction Polymorphism, Single Nucleotide Promoter Regions, Genetic Proteins Rheumatoid arthritis Rodents Veterinary colleges Veterinary medicine |
| title | Chemokine (C-C motif) ligand 2 (CCL2) in sera of patients with type 1 diabetes and diabetic complications |
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