Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)--positive rheumatoid arthritis in three Asian ethnic groups

To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia. 1,079 rheumatoid arthritis patients and 1,470 healthy controls were included in the study. Leve...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21069-e21069
Hauptverfasser:	Chun-Lai, Too, Padyukov, Leonid, Dhaliwal, Jasbir Singh, Lundström, Emeli, Yahya, Abqariyah, Muhamad, Nor Asiah, Klareskog, Lars, Alfredsson, Lars, Larsson, Per Tobias, Murad, Shahnaz
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Alleles Antibodies Antibodies - chemistry Antibodies - genetics Antigenic determinants Arthritis Asia - ethnology Autoantibodies Autoimmunity Biology Citrulline Citrulline - immunology Drb1 protein Environmental health Epidemiology Epitopes Epitopes - genetics Ethnic Groups Female Gene frequency Genotyping Health risk assessment Histocompatibility antigen HLA HLA antigens HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Immunology Male Medical research Medicine Minority & ethnic groups Patients Population Populations Proteins Rheumatism Rheumatoid arthritis Rheumatoid factor Rheumatoid Factor - immunology Rheumatology Risk Factors Studies
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