Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli

Ileal lesions in Crohn's disease (CD) patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to adhere to and invade intestinal epithelial cells (IEC), and to survive within macrophages. The interaction of AIEC with IEC depends on bacterial factors mainly type 1 pil...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21199-e21199
Hauptverfasser:	Vazeille, Emilie, Bringer, Marie-Agnès, Gardarin, Aurélie, Chambon, Christophe, Becker-Pauly, Christoph, Pender, Sylvia L F, Jakob, Christine, Müller, Stefan, Lottaz, Daniel, Darfeuille-Michaud, Arlette
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Bacteria Bacterial Adhesion - physiology Biodegradation Biology Biopsy Colon Colonization Crohn Disease - microbiology Crohn Disease - physiopathology Crohn's Disease Crohns disease Cytokines E coli Epithelial cells Escherichia coli Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli - physiology Female Flagella Food and Nutrition Gastroenterology Gastrointestinal diseases Haemophilus Human health and pathology Humans Inflammation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 8 Interleukin-8 - secretion Intestinal Mucosa - microbiology Intestinal Mucosa - physiopathology Intestine Kinases Lesions Life Sciences Macrophages Male Medicine Membrane proteins Metalloendopeptidases - physiology Mice Mice, Inbred C57BL Middle Aged Mucosa Neutrophils Outer membrane proteins Patients Pili Protease Proteases Proteinase Proteins Proteolysis Pseudomonas aeruginosa Receptors Rodents
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