Natural selection and adaptive evolution of leptin in the ochotona family driven by the cold environmental stress

Environmental stress can accelerate the evolutionary rate of specific stress-response proteins and create new functions specialized for different environments, enhancing an organism's fitness to stressful environments. Pikas (order Lagomorpha), endemic, non-hibernating mammals in the modern Hol...

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Veröffentlicht in:	PloS one 2008-01, Vol.3 (1), p.e1472
Hauptverfasser:	Yang, Jie, Wang, Zhen Long, Zhao, Xin Quan, Wang, De Peng, Qi, De Lin, Xu, Bao Hong, Ren, Yong Hong, Tian, Hui Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adaptation Adaptation, Physiological Amino Acid Sequence Amino acid substitution Amino acids Animals ATP synthase Bioinformatics Biological evolution Biology Cloning, Molecular Cold Cold regions Cold Temperature Deoxyribonucleic acid Disease control Disease prevention DNA DNA, Complementary Ecological adaptation Ecology/Evolutionary Ecology Ecology/Physiological Ecology Energy balance Energy metabolism Environmental factors Environmental stress Evolution Evolution & development Evolutionary Biology/Bioinformatics Evolutionary Biology/Evolutionary and Comparative Genetics Evolutionary Biology/Evolutionary Ecology Fitness Gene expression Genetic research High-altitude environments Homeostasis Hypoxia Kinases Laboratories Lagomorpha Leptin Leptin - chemistry Leptin - genetics Leptin - physiology Likelihood Functions Metabolism Mitochondrial DNA Molecular Biology/Bioinformatics Molecular Biology/Molecular Evolution Molecular evolution Molecular Sequence Data Mutation Natural selection Nucleotide sequence Ochotona Phylogenetics Phylogeny Physiological aspects Positive selection Proteins Regression analysis Reproductive fitness Selection, Genetic Sequence Homology, Amino Acid Spatial distribution Statistical methods Steppes Stresses Thermogenesis
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