Systematic dissection of roles for chromatin regulators in a yeast stress response

Packaging of eukaryotic genomes into chromatin has wide-ranging effects on gene transcription. Curiously, it is commonly observed that deletion of a global chromatin regulator affects expression of only a limited subset of genes bound to or modified by the regulator in question. However, in many sin...

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Veröffentlicht in:	PLoS biology 2012-07, Vol.10 (7), p.e1001369
Hauptverfasser:	Weiner, Assaf, Chen, Hsiuyi V, Liu, Chih Long, Rahat, Ayelet, Klien, Avital, Soares, Luis, Gudipati, Mohanram, Pfeffner, Jenna, Regev, Aviv, Buratowski, Stephen, Pleiss, Jeffrey A, Friedman, Nir, Rando, Oliver J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Chromatin Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly Chromatin Immunoprecipitation Diamide - pharmacology Gene expression Gene Expression Profiling Gene Expression Regulation, Fungal Genes, Fungal Genetic aspects Genetic transcription Genetics Health aspects Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones - genetics Histones - metabolism Methylation Nucleosomes - genetics Nucleosomes - metabolism Phosphorylation Physiological aspects Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Ribosomes - genetics Ribosomes - metabolism Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Deletion Stress, Physiological Studies Substrate Specificity Time Factors Time-Lapse Imaging - methods Transcription, Genetic Yeast Yeast fungi
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