Endoplasmic reticulum stress pathway-mediated apoptosis in macrophages contributes to the survival of Mycobacterium tuberculosis

Apoptosis is thought to play a role in host defenses against intracellular pathogens, including Mycobacterium tuberculosis (Mtb), by preventing the release of intracellular components and the spread of mycobacterial infection. This study aims to investigate the role of endoplasmic reticulum (ER) str...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e28531-e28531
Hauptverfasser:	Lim, Yun-Ji, Choi, Ji-Ae, Choi, Hong-Hee, Cho, Soo-Na, Kim, Hwa-Jung, Jo, Eun-Kyeong, Park, Jeong-Kyu, Song, Chang-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Apoptosis Bacterial infections Biomarkers - metabolism Caspase Caspase-12 Caspases - metabolism Cell death Cell Line Cell survival Cytotoxicity Disease transmission Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - microbiology Endoplasmic Reticulum Stress - genetics Enzyme Activation Eukaryotic Initiation Factor-2B - metabolism Gene Expression Regulation Health aspects Humans Infections Intracellular Intracellular Space - metabolism Intracellular Space - microbiology Kinases Macrophages Macrophages - cytology Macrophages - enzymology Macrophages - microbiology Medical research Medicine Metabolic Networks and Pathways Mice Microbial Viability Mycobacterium tuberculosis Mycobacterium tuberculosis - cytology Mycobacterium tuberculosis - physiology Oxidative stress Pathogenesis Phosphorylation Protein synthesis Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Sepsis Stresses Survival Thyroid cancer Time Factors Transcription Factor CHOP - metabolism Tuberculosis Tuberculosis - microbiology Tuberculosis - pathology Yersinia pestis
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