Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy

Meesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, the outermost covering of the eye. Typically, patients suffer from lifelong irritation of...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e28582-e28582
Hauptverfasser:	Liao, Haihui, Irvine, Alan D, Macewen, Caroline J, Weed, Kathryn H, Porter, Louise, Corden, Laura D, Gibson, A Bethany, Moore, Jonathan E, Smith, Frances J D, McLean, W H Irwin, Moore, C B Tara
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Alleles Base Sequence Biology Care and treatment Cell culture Cells, Cultured Confidence limits Cornea Corneal dystrophy Corneal Dystrophy, Juvenile Epithelial of Meesmann - genetics Corneal Dystrophy, Juvenile Epithelial of Meesmann - therapy Dentistry Dystrophy Enzymes Epithelium Eye Eye diseases Feasibility studies Filaments Fragility Gene expression Gene mutation Gene Silencing Gene Transfer Techniques Genetic aspects Genotype & phenotype Health aspects Hereditary diseases Hospitals Humans Inhibitors Irritation Keratin Keratins Keratins - chemistry Life sciences Medical research Medicine Missense mutation Molecular Sequence Data Mutant Proteins - chemistry Mutation Nursing Ophthalmology Protein Structure, Quaternary Proteins RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use Scars siRNA Surgery Topography Transfection Visual acuity
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