Mechanisms of MEOX1 and MEOX2 Regulation of the Cyclin Dependent Kinase Inhibitors p21CIP1/WAF1 and p16INK4a in Vascular Endothelial Cells

Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21CIP1/WAF1 and p16INK4a govern the G1/S cell cycle checkpoint and are essential for determining whether a cell enters into an arre...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e29099
Hauptverfasser:	Douville, Josette M., Cheung, David Y. C., Herbert, Krista L., Moffatt, Teri, Wigle, Jeffrey T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Arteriosclerosis Atherosclerosis Binding Biochemistry Biology Cell cycle Cell growth Cell proliferation Cyclin-dependent kinase inhibitor p21 Cyclin-dependent kinases Deoxyribonucleic acid DNA Endothelial cells Enzyme inhibitors Gene expression Genes Genomes Homeobox Hospitals Inhibitors INK4a protein Kinases Medicine p16 Protein Proteins Rodents Senescence Smooth muscle Transcription activation Transcription factors
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