Age-related neural dedifferentiation in the motor system
Recent neuroimaging studies using multi-voxel pattern analysis (MVPA) show that distributed patterns of brain activation elicited by different visual stimuli are less distinctive in older adults than in young adults. However, less is known about the effects of aging on the neural representation of m...
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| Veröffentlicht in: | PloS one 2011-12, Vol.6 (12), p.e29411-e29411 |
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| creator | Carp, Joshua Park, Joonkoo Hebrank, Andrew Park, Denise C Polk, Thad A |
| description | Recent neuroimaging studies using multi-voxel pattern analysis (MVPA) show that distributed patterns of brain activation elicited by different visual stimuli are less distinctive in older adults than in young adults. However, less is known about the effects of aging on the neural representation of movement. The present study used MVPA to compare the distinctiveness of motor representations in young and older adults. We also investigated the contributions of brain structure to age differences in the distinctiveness of motor representations. We found that neural distinctiveness was reduced in older adults throughout the motor control network. Although aging was also associated with decreased gray matter volume in these regions, age differences in motor distinctiveness remained significant after controlling for gray matter volume. Our results suggest that age-related neural dedifferentiation is not restricted to sensory perception and is instead a more general feature of the aging brain. |
| doi_str_mv | 10.1371/journal.pone.0029411 |
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However, less is known about the effects of aging on the neural representation of movement. The present study used MVPA to compare the distinctiveness of motor representations in young and older adults. We also investigated the contributions of brain structure to age differences in the distinctiveness of motor representations. We found that neural distinctiveness was reduced in older adults throughout the motor control network. Although aging was also associated with decreased gray matter volume in these regions, age differences in motor distinctiveness remained significant after controlling for gray matter volume. Our results suggest that age-related neural dedifferentiation is not restricted to sensory perception and is instead a more general feature of the aging brain.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0029411</identifier><identifier>PMID: 22216274</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Age composition ; Age differences ; Aged ; Aging ; Aging - physiology ; Biology ; Brain ; Brain - cytology ; Brain - physiology ; Brain research ; Cell Differentiation ; Dopamine ; Female ; Gerontology ; Humans ; Hypotheses ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medicine ; Middle Aged ; Motor task performance ; Neural coding ; Neurobiology ; Neuroimaging ; Neurology ; Neurons ; Neurosciences ; Older people ; Pattern analysis ; Representations ; Sensory perception ; Social and Behavioral Sciences ; Standard deviation ; Studies ; Subconscious ; Substantia grisea ; Trends ; Visual stimuli ; Young Adult ; Young adults</subject><ispartof>PloS one, 2011-12, Vol.6 (12), p.e29411-e29411</ispartof><rights>2011 Carp et al.</rights><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Carp et al. 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However, less is known about the effects of aging on the neural representation of movement. The present study used MVPA to compare the distinctiveness of motor representations in young and older adults. We also investigated the contributions of brain structure to age differences in the distinctiveness of motor representations. We found that neural distinctiveness was reduced in older adults throughout the motor control network. Although aging was also associated with decreased gray matter volume in these regions, age differences in motor distinctiveness remained significant after controlling for gray matter volume. Our results suggest that age-related neural dedifferentiation is not restricted to sensory perception and is instead a more general feature of the aging brain.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22216274</pmid><doi>10.1371/journal.pone.0029411</doi><tpages>e29411</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Adults Age Age composition Age differences Aged Aging Aging - physiology Biology Brain Brain - cytology Brain - physiology Brain research Cell Differentiation Dopamine Female Gerontology Humans Hypotheses Magnetic Resonance Imaging Male Medical imaging Medicine Middle Aged Motor task performance Neural coding Neurobiology Neuroimaging Neurology Neurons Neurosciences Older people Pattern analysis Representations Sensory perception Social and Behavioral Sciences Standard deviation Studies Subconscious Substantia grisea Trends Visual stimuli Young Adult Young adults |
| title | Age-related neural dedifferentiation in the motor system |
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