Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer

GLI1, as an indispensable transcriptional factor of Hedgehog signaling pathway, plays an important role in the development of pancreatic cancer (PC). DNA methyltransferases (DNMTs) mediate the methylation of quantity of tumor-related genes. Our study aimed to explore the relationship between GLI1 an...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27684
Hauptverfasser:	He, ShanShan, Wang, Feng, Yang, LiJuan, Guo, ChuanYong, Wan, Rong, Ke, AiWu, Xu, Ling, Hu, GuoYong, Xu, XuanFu, Shen, Jie, Wang, XingPeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - metabolism Adenomatous Polyposis Coli - pathology Biology Cancer Cell cycle Cell Line, Tumor Chromatin Colorectal cancer Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA Methylation - drug effects DNA Methylation - genetics DNMT1 protein Ethics Gastroenterology Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genes GLI1 gene Gli1 protein Hedgehog protein Hepatitis Hospitals Humans Immunohistochemistry Immunoprecipitation Leukemia Ligands Liver cancer Lung cancer Medical prognosis Medicine Metastasis Methylation Methyltransferases MicroRNAs Oncogene Proteins - deficiency Oncogene Proteins - genetics Oncogene Proteins - metabolism Overexpression Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Protein binding RNA RNA, Small Interfering - genetics Signal transduction Signaling siRNA Tissues Trans-Activators - deficiency Trans-Activators - genetics Trans-Activators - metabolism Transfection Up-Regulation - drug effects Up-Regulation - genetics Veratrum Alkaloids - pharmacology Zinc Finger Protein GLI1
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