Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione

Linear heteroareneanthracenediones have been shown to interfere with DNA functions, thereby causing death of human tumor cells and their drug resistant counterparts. Here we report the interaction of our novel antiproliferative agent 4,11-bis[(2-{[acetimido]amino}ethyl)amino]anthra[2,3-b]thiophene-5...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27151
Hauptverfasser:	Kaluzhny, Dmitry, Ilyinsky, Nikolay, Shchekotikhin, Andrei, Sinkevich, Yuri, Tsvetkov, Philipp O, Tsvetkov, Vladimir, Veselovsky, Alexander, Livshits, Mikhail, Borisova, Olga, Shtil, Alexander, Shchyolkina, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption spectroscopy Affinity Anthraquinones - chemical synthesis Anthraquinones - pharmacology Antibiotics Antiproliferatives Binding Biology Calorimetry Cancer Cell Proliferation - drug effects Circular Dichroism Colonic Neoplasms - drug therapy Cytotoxicity Deoxyribonucleic acid Dichroism DNA Drug resistance Drugs G-Quadruplexes - drug effects Glycoproteins Humans Leukemia - drug therapy Medicine Models, Molecular Molecular biology Molecular dynamics Molecular Dynamics Simulation Nucleic Acid Conformation - drug effects Oligonucleotides Oligonucleotides - genetics Oligonucleotides - metabolism Potassium - metabolism Sodium - metabolism Spectroscopy Telomerase Telomere - genetics Telomere - metabolism Thiophene Thiophenes - chemical synthesis Thiophenes - pharmacology Titration Titration calorimetry Tumor cells Tumor Cells, Cultured Ultraviolet absorption
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