Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes

MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain elusive. We hypothesized that miRs that figure pro...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27417-e27417
Hauptverfasser:	Fu, Ji-Dong, Rushing, Stephanie N, Lieu, Deborah K, Chan, Camie W, Kong, Chi-Wing, Geng, Lin, Wilson, Kitchener D, Chiamvimonvat, Nipavan, Boheler, Kenneth R, Wu, Joseph C, Keller, Gordon, Hajjar, Roger J, Li, Ronald A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging Analysis Animals Biology Calcium Calcium - metabolism Cardiomyocytes Cell Differentiation Cell Line Consortia Differentiation Electrophysiological Phenomena - genetics Embryo cells Embryonic stem cells Embryonic Stem Cells - cytology Experiments Fetus - cytology Fetuses Genes Heart Heart cells Heart diseases Heart failure Heart Ventricles - cytology Heart Ventricles - metabolism Humans Kinetics Maturation Medicine Mice MicroRNA MicroRNAs MicroRNAs - metabolism miRNA Morphogenesis Muscle contraction Mutation Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Myogenesis Pathogenesis Pluripotency Ribonucleic acid RNA Specifications Stem cell transplantation Stem cells Transcription Transcription factors Ventricle Ventricular Function - genetics
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