A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death

Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF receptor (TNFR) 1 is predominantly associated with neurodegeneration, TNFR2 is involved in tissue regeneration and neuroprotection. Accordingly, the availability of TNFR2-selective agonists could allow the devel...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27621
Hauptverfasser:	Fischer, Roman, Maier, Olaf, Siegemund, Martin, Wajant, Harald, Scheurich, Peter, Pfizenmaier, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation AKT protein Alzheimer's disease Alzheimers disease Animals Apoptosis Biochemistry Biological activity Biology Cell death Cell Death - drug effects Cell Differentiation - drug effects Chromatography Complex formation Dopamine Dopamine receptors Dopaminergic Neurons - cytology Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Downstream effects Enzymes Gene Expression Regulation - drug effects Genetic engineering Health aspects HEK293 Cells Homeostasis Humans Hydrogen peroxide Hypotheses Immunology Internal medicine Medical treatment Medicine Mice Mortality Movement disorders Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurological diseases Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Oxidation Oxidative stress Oxidative Stress - drug effects Parkinson disease Parkinson's disease Parkinsons disease Pathogenesis Pathways Peptides Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proteins Proto-Oncogene Proteins c-akt - metabolism Receptors, Tumor Necrosis Factor, Type II - agonists Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - pharmacology Regeneration Restoration Signal transduction Signal Transduction - drug effects Signaling Solubility Substrate Specificity Superoxides - pharmacology Tenascin Tenascin - chemistry Tenascin - pharmacology Tenascin C Tissue engineering Trends Tumor necrosis factor Tumor necrosis factor receptors Tumor necrosis factor-TNF
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