Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice

Microparticles are membrane vesicles with pro-inflammatory properties. Circulating levels of microparticles have previously been found to be elevated in patients with metabolic syndrome (MetS). The present study aimed to evaluate the effects of in vivo treatment with microparticles, from patients wi...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27809-e27809
Hauptverfasser:	Agouni, Abdelali, Ducluzeau, Pierre-Henri, Benameur, Tarek, Faure, Sébastien, Sladkova, Martina, Duluc, Lucie, Leftheriotis, Georges, Pechanova, Olga, Delibegovic, Mirela, Martinez, Maria Carmen, Andriantsitohaina, Ramaroson
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Aorta - cytology Aorta - metabolism Apoptosis Arginine Atherosclerosis Biology Blood platelets Cardiovascular disease Cell-Derived Microparticles - metabolism Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Contractility COX-2 inhibitors Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Diabetes Environmental science Ethics Fas Ligand Protein - metabolism fas Receptor - metabolism FasL protein Female Gene Expression Regulation, Enzymologic Health care Humans Hypertension In vivo methods and tests Inflammation Kinases Laboratory animals Ligands Male Medical research Medicine Membrane vesicles Metabolic disorders Metabolic syndrome Metabolic Syndrome - pathology Metabolites Mice Microparticles Middle Aged Monocyte chemoattractant protein Monocyte chemoattractant protein 1 NAD(P)H oxidase NADPH Oxidases - metabolism Neutralization Nitric oxide Nitric Oxide - metabolism Oxygen Oxygenase Pathogenesis Patients Prostacyclin Prostaglandin endoperoxide synthase Reactive oxygen species Reactive Oxygen Species - metabolism Reactivity Rodents Serotonin Signal Transduction Smooth muscle Thrombosis
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