Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health--a randomized controlled clinical pilot study

Cardiovascular diseases are expanding to a major social-economic burden in the Western World and undermine man's deep desire for healthy ageing. Epidemiological studies suggest that flavanol-rich foods (e.g. grapes, wine, chocolate) sustain cardiovascular health. For an evidenced-based applicat...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e28460
Hauptverfasser:	Weseler, Antje R, Ruijters, Erik J B, Drittij-Reijnders, Marie-José, Reesink, Koen D, Haenen, Guido R M M, Bast, Aalt
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antioxidants Antioxidants (Nutrients) Antioxidants - metabolism Bacteria Biomarkers Blood Vessels - drug effects Blood Vessels - physiology C-reactive protein Cardiovascular diseases Chemistry Chocolate Cholesterol Cigarettes Clinical trials Data processing Diet Dietary Supplements Disease Endothelin 1 Endothelins Enzymes Epidemiology Erythrocytes Fibrin Fibrinogen Fibrinogen - metabolism Flavanols Flavonols - pharmacology Food Free radicals Gene expression Glutathione Grapes Health Heart diseases Humans Inflammation Inflammation - blood Inflammation - pathology Leukocytes Lipid metabolism Lipids - blood Low density lipoprotein Low density lipoproteins Male Medicine Metabolism Microvasculature Middle Aged Nitric oxide Nutrition research Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Physiological aspects Pilot Projects Plasma levels Platelet aggregation Platelet Aggregation - drug effects Platelets Polyphenols Randomization Rodents Seeds Smokers Smoking Stress response Studies Toxicology Vegetarianism Vitis - chemistry Vitis vinifera Wine Wines
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