MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex

In heart failure (HF), arrhythmogenic spontaneous sarcoplasmic reticulum (SR) Ca(2+) release and afterdepolarizations in cardiac myocytes have been linked to abnormally high activity of ryanodine receptors (RyR2s) associated with enhanced phosphorylation of the channel. However, the specific molecul...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e28324-e28324
Hauptverfasser:	Belevych, Andriy E, Sansom, Sarah E, Terentyeva, Radmila, Ho, Hsiang-Ting, Nishijima, Yoshinori, Martin, Mickey M, Jindal, Hitesh K, Rochira, Jennifer A, Kunitomo, Yukiko, Abdellatif, Maha, Carnes, Cynthia A, Elton, Terry S, Györke, Sandor, Terentyev, Dmitry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmia Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Biology Ca2+/calmodulin-dependent protein kinase II Calcium (reticular) Calcium - metabolism Calcium binding proteins Calcium signalling Calcium-binding protein Calmodulin Cardiology Cardiomyocytes Cardiomyopathy Catalysis Catalytic Domain Dogs Electrophysiology - methods Fibroblasts Gene expression Genes, Reporter Heart Heart attacks Heart diseases Heart failure Heart Failure - complications Heart Failure - metabolism Heart Ventricles - pathology Hospitals Humans Isoproterenol - pharmacology Kinases Luciferase Medical schools Medicine MicroRNA MicroRNAs MicroRNAs - metabolism miRNA Models, Biological Molecular modelling Muscle Cells - metabolism Muscle contraction Muscles Myocytes Pharmacology Pharmacy Phosphatase Phosphatases Phosphoprotein phosphatase Phosphoric Monoester Hydrolases - metabolism Phosphorylation Physiology Protein folding Protein phosphatase Proteins Receptors Receptors, Adrenergic, beta - metabolism Regulatory subunits Ribonucleic acid RNA RNA, Messenger - metabolism Rodents Ryanodine Receptor Calcium Release Channel - metabolism Ryanodine receptors Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Ventricle Veterinary Science
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