The tyrosine kinase inhibitor dasatinib induces a marked adipogenic differentiation of human multipotent mesenchymal stromal cells

The introduction of specific BCR-ABL inhibitors in chronic myelogenous leukemia therapy has entirely mutated the prognosis of this hematologic cancer from being a fatal disorder to becoming a chronic disease. Due to the probable long lasting treatment with tyrosine-kinase inhibitors (TKIs), the know...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e28555-e28555
Hauptverfasser:	Borriello, Adriana, Caldarelli, Ilaria, Basile, Maria Assunta, Bencivenga, Debora, Tramontano, Annunziata, Perrotta, Silverio, Della Ragione, Fulvio, Oliva, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl protein Adipocytes - cytology Adipogenesis Adipogenesis - drug effects Alkaline phosphatase Antineoplastic agents Antineoplastic Agents - pharmacology BCR protein BCR-ABL protein Biochemistry Biocompatibility Biology Biomedical materials Biophysics Bone marrow Bone Marrow Cells - drug effects Cancer Cancer treatment Cell Differentiation - drug effects Chronic diseases Chronic illnesses Chronic myeloid leukemia Colorectal cancer Dasatinib Dexamethasone Differentiation Enzyme inhibitors Fibroblasts Fusion protein Glucocorticoids Growth factors Humans Immunoglobulins Inhibitors K562 Cells Kinases Laboratories Leukemia Lung cancer Medical prognosis Medical treatment Medicine Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Mesoderm - drug effects Mineralization Myeloid leukemia Neoplasms - drug therapy Osteoblasts - cytology Ovarian cancer Oxidative stress Phenols (Class of compounds) Phenotype Phosphatases Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Pyrimidines - pharmacology Stem cells Stromal cells Stromal Cells - drug effects Studies Therapy Thiazoles - pharmacology Tyrosine Tyrosine kinase inhibitors
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