A novel multiplex cell viability assay for high-throughput RNAi screening

Cell-based high-throughput RNAi screening has become a powerful research tool in addressing a variety of biological questions. In RNAi screening, one of the most commonly applied assay system is measuring the fitness of cells that is usually quantified using fluorescence, luminescence and absorption...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e28338-e28338
Hauptverfasser:	Gilbert, Daniel F, Erdmann, Gerrit, Zhang, Xian, Fritzsche, Anja, Demir, Kubilay, Jaedicke, Andreas, Muehlenberg, Katja, Wanker, Erich E, Boutros, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Analysis Apoptosis Assaying Benzimidazoles - pharmacology Biology Cell lines Cell Survival Cytoplasm - metabolism False Positive Reactions Fitness Fluoresceins - pharmacology Fluorescence Fluorescent Dyes - pharmacology Genomics HEK293 Cells Humans Indicators Intersections Medical screening Multiplexing Mutation Neurodegeneration Phenotype Reproducibility of Results Research Design RNA Interference RNA, Small Interfering - metabolism RNA-mediated interference Screening siRNA Tumors
Online-Zugang:	Volltext
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