The E1B19K oncoprotein complexes with Beclin 1 to regulate autophagy in adenovirus-infected cells

The mechanisms underlying adenovirus-mediated autophagy are currently unknown. Recently, members of the Bcl-2 protein family have been associated with autophagy. It was also reported that the Bcl-2 homology-3 (BH3) domain encompassed by both Beclin 1 and Bcl-2-like proteins is essential for their pr...

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Veröffentlicht in:	PloS one 2011-12, Vol.6 (12), p.e29467-e29467
Hauptverfasser:	Piya, Sujan, White, Erin J, Klein, Sarah R, Jiang, Hong, McDonnell, Timothy J, Gomez-Manzano, Candelaria, Fueyo, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenoviridae - physiology Adenoviridae Infections - enzymology Adenoviridae Infections - metabolism Adenoviridae Infections - pathology Adenovirus E1B Proteins - metabolism Adenoviruses Apoptosis Apoptosis Regulatory Proteins - metabolism Autophagy B cells Bcl-2 protein Beclin-1 Biology Cancer Cell death Cell Line Clonal deletion Enzyme Activation Experiments Gene deletion Homology Humans Hypotheses Immunoprecipitation Infections Kinases Localization Medicine Membrane Proteins - metabolism Models, Biological Oncology Oncoproteins Phagocytosis Phagosomes Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological aspects Protein Binding Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Recruitment Viral proteins Viruses
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