Genome-wide binding map of the HIV-1 Tat protein to the human genome

The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. While Tat's control of viral transcription is well-studied, much less is known about the interaction of Tat with the human genome....

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e26894-e26894
Hauptverfasser:	Marban, Céline, Su, Trent, Ferrari, Roberto, Li, Bing, Vatakis, Dimitrios, Pellegrini, Matteo, Zack, Jerome A, Rohr, Olivier, Kurdistani, Siavash K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Apoptosis Binding Binding sites Bioinformatics Biology Cells (Biology) Chemokines Chromatin Chromatin Immunoprecipitation Cytokines Deoxyribonucleic acid DNA DNA methylation Ets-1 protein Gene expression Gene Products, tat - metabolism Gene sequencing Genes Genetic aspects Genome, Human Genomes Genomics Hematology Histone acetyltransferase Histone H3 Histones HIV HIV-1 - metabolism Human immunodeficiency virus Humans Immune response Immune system Immunoprecipitation Introns Jurkat Cells Kinases Life cycle engineering Life cycles Life Sciences Lymphocytes Lymphocytes T Lysine Medical research Medicine Methylation Microbiology and Parasitology Nucleotide sequence Promoters Protein Binding Proteins RNA polymerase Stem cells T cells Tat protein Transcription (Genetics) Transcription factors Virology
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