Reduction of plasma gelsolin levels correlates with development of multiple organ dysfunction syndrome and fatal outcome in burn patients
Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in critically ill surgical patients. We hypothesized that the extent of pGSN reduction might correlate with different outcome of burn patients. The study was performed to evaluate the prognostic implication...
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| creator | Huang, Li-feng Yao, Yong-ming Li, Jin-feng Dong, Ning Liu, Chen Yu, Yan He, Li-xin Sheng, Zhi-yong |
| description | Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in critically ill surgical patients. We hypothesized that the extent of pGSN reduction might correlate with different outcome of burn patients. The study was performed to evaluate the prognostic implications of pGSN levels on the development of multiple organ dysfunction syndrome (MODS) and fatal outcome in a group of severely burn patients.
95 patients were included, and they were divided into three groups with different burn area: group I (n = 33), group II (n = 32) and group III (n = 30). According to whether there was development of MODS or not, patients were divided into MODS group (n = 28) and none-MODS group (n = 67); then the patients with MODS were further divided into non-survivor group (n = 17) and survivor group (n = 11). The peripheral blood samples were collected on postburn days (PBD) 1, 3, 7, 14, and 21. The levels of pGSN were determined and T cells were procured from the blood. The contents of cytokines (IL-2, IL-4 and IFN-γ) released by T cells were also measured. The related factors of prognosis were analyzed by using multivariate logistic regression analysis. The results showed that pGSN concentrations, as well as the levels of IL-2 and IFN-γ, decreased markedly on PBD 1-21, whereas, the levels of IL-4 increased markedly in all burn groups as compared with normal controls (P |
| doi_str_mv | 10.1371/journal.pone.0025748 |
| format | Article |
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95 patients were included, and they were divided into three groups with different burn area: group I (n = 33), group II (n = 32) and group III (n = 30). According to whether there was development of MODS or not, patients were divided into MODS group (n = 28) and none-MODS group (n = 67); then the patients with MODS were further divided into non-survivor group (n = 17) and survivor group (n = 11). The peripheral blood samples were collected on postburn days (PBD) 1, 3, 7, 14, and 21. The levels of pGSN were determined and T cells were procured from the blood. The contents of cytokines (IL-2, IL-4 and IFN-γ) released by T cells were also measured. The related factors of prognosis were analyzed by using multivariate logistic regression analysis. The results showed that pGSN concentrations, as well as the levels of IL-2 and IFN-γ, decreased markedly on PBD 1-21, whereas, the levels of IL-4 increased markedly in all burn groups as compared with normal controls (P<0.05 or P<0.01), and there were obviously differences between group I and group III (P<0.05 or P<0.01). The similar results were found in MODS patients and the non-survivor group as compared with those without MODS and the survival group on days 3-21 postburn (P<0.05 or P<0.01). Moreover, as the pGSN levels decreased, the incidence of septic complication as well as MODS remarkably increased.
pGSN levels appear to be an early prognostic marker in patients suffering from major burns.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0025748</identifier><identifier>PMID: 22069445</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Actin ; Adult ; Analysis ; Binding proteins ; Biology ; Blood ; Burn patients ; Burns ; Burns - blood ; Burns - complications ; Case-Control Studies ; Cytokines ; Dendritic cells ; Enzyme-Linked Immunosorbent Assay ; Female ; Gelsolin ; Gelsolin - blood ; Hospitals ; Humans ; Immunology ; Interferon ; Interleukin 2 ; Interleukin 4 ; Interleukin-2 - blood ; Interleukin-4 - blood ; Lymphocytes ; Lymphocytes T ; Male ; Medical research ; Medicine ; Metabolism ; Mortality ; Multiple organ dysfunction syndrome ; Multiple Organ Failure - blood ; Multiple Organ Failure - etiology ; Multiple Organ Failure - mortality ; Muscle proteins ; Musculoskeletal system ; Patient outcomes ; Patients ; Peripheral blood ; Permeability ; Plasma ; Prognosis ; Protein binding ; Proteins ; Reduction ; Regression analysis ; Rodents ; Sepsis ; Studies ; Surgery ; Survival Rate ; T cells ; T-Lymphocytes - metabolism ; Trauma ; γ-Interferon</subject><ispartof>PloS one, 2011-11, Vol.6 (11), p.e25748-e25748</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Huang et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c761t-222ebcdd457e1e638f3352e1d15d19f4a5ffc1c783917a67342801c9e95ffef53</citedby><cites>FETCH-LOGICAL-c761t-222ebcdd457e1e638f3352e1d15d19f4a5ffc1c783917a67342801c9e95ffef53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206022/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206022/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22069445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Egles, Christophe</contributor><creatorcontrib>Huang, Li-feng</creatorcontrib><creatorcontrib>Yao, Yong-ming</creatorcontrib><creatorcontrib>Li, Jin-feng</creatorcontrib><creatorcontrib>Dong, Ning</creatorcontrib><creatorcontrib>Liu, Chen</creatorcontrib><creatorcontrib>Yu, Yan</creatorcontrib><creatorcontrib>He, Li-xin</creatorcontrib><creatorcontrib>Sheng, Zhi-yong</creatorcontrib><title>Reduction of plasma gelsolin levels correlates with development of multiple organ dysfunction syndrome and fatal outcome in burn patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in critically ill surgical patients. We hypothesized that the extent of pGSN reduction might correlate with different outcome of burn patients. The study was performed to evaluate the prognostic implications of pGSN levels on the development of multiple organ dysfunction syndrome (MODS) and fatal outcome in a group of severely burn patients.
95 patients were included, and they were divided into three groups with different burn area: group I (n = 33), group II (n = 32) and group III (n = 30). According to whether there was development of MODS or not, patients were divided into MODS group (n = 28) and none-MODS group (n = 67); then the patients with MODS were further divided into non-survivor group (n = 17) and survivor group (n = 11). The peripheral blood samples were collected on postburn days (PBD) 1, 3, 7, 14, and 21. The levels of pGSN were determined and T cells were procured from the blood. The contents of cytokines (IL-2, IL-4 and IFN-γ) released by T cells were also measured. The related factors of prognosis were analyzed by using multivariate logistic regression analysis. The results showed that pGSN concentrations, as well as the levels of IL-2 and IFN-γ, decreased markedly on PBD 1-21, whereas, the levels of IL-4 increased markedly in all burn groups as compared with normal controls (P<0.05 or P<0.01), and there were obviously differences between group I and group III (P<0.05 or P<0.01). The similar results were found in MODS patients and the non-survivor group as compared with those without MODS and the survival group on days 3-21 postburn (P<0.05 or P<0.01). Moreover, as the pGSN levels decreased, the incidence of septic complication as well as MODS remarkably increased.
pGSN levels appear to be an early prognostic marker in patients suffering from major burns.]]></description><subject>Acids</subject><subject>Actin</subject><subject>Adult</subject><subject>Analysis</subject><subject>Binding proteins</subject><subject>Biology</subject><subject>Blood</subject><subject>Burn patients</subject><subject>Burns</subject><subject>Burns - blood</subject><subject>Burns - complications</subject><subject>Case-Control Studies</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gelsolin</subject><subject>Gelsolin - blood</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunology</subject><subject>Interferon</subject><subject>Interleukin 2</subject><subject>Interleukin 4</subject><subject>Interleukin-2 - blood</subject><subject>Interleukin-4 - blood</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Multiple organ dysfunction syndrome</subject><subject>Multiple Organ Failure - blood</subject><subject>Multiple Organ Failure - etiology</subject><subject>Multiple Organ Failure - mortality</subject><subject>Muscle proteins</subject><subject>Musculoskeletal system</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Permeability</subject><subject>Plasma</subject><subject>Prognosis</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Reduction</subject><subject>Regression analysis</subject><subject>Rodents</subject><subject>Sepsis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>T cells</subject><subject>T-Lymphocytes - metabolism</subject><subject>Trauma</subject><subject>γ-Interferon</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9uKFDEQhhtR3HX1DUQDguLFjDn16UZYFg8DCwvr4TZkkspMhnSn7aRX5xF8a9NO7zIteyF90aHy_X9Slaose07wkrCSvNv5oW-lW3a-hSXGNC959SA7JTWji4Ji9vBofZI9CWGHcc6qonicnVCKi5rz_DT7fQ16UNH6FnmDOidDI9EGXPDOtsjBTVoi5fsenIwQ0E8bt0iPYd810MZR1Qwu2s4B8v1Gtkjvgxnag2fYt7r3DSDZamRklA75IaoxkuzXKQPUyWiTUXiaPTLSBXg2_c-ybx8_fL34vLi8-rS6OL9cqLIgcUEphbXSmuclEChYZRjLKRBNck1qw2VujCKqrFhNSlmUjNMKE1VDnTbA5Owse3nw7ZwPYqpiEIQRXJZ5xUgiVgdCe7kTXW8b2e-Fl1b8DaQsheyjVQ6EUlTlXHHDaMkLVldrwmqoZKXyVGsik9f76bRh3YBWKdNeupnpfKe1W7HxN4KlJ8KUJoM3k0HvfwwQomhsUOCcbMEPQdSYEZ7jqkjkq3_I-5ObqI1M97et8elYNXqKc14WyaeoWKKW91Dp09BYlTrO2BSfCd7OBImJ8Ctu5BCCWH25_n_26vucfX3EbkG6uE29OYzdFeYgP4Cq9yH0YO5qTLAYB-a2GmIcGDENTJK9OH6fO9HthLA_3xYTPQ</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Huang, Li-feng</creator><creator>Yao, Yong-ming</creator><creator>Li, Jin-feng</creator><creator>Dong, Ning</creator><creator>Liu, Chen</creator><creator>Yu, Yan</creator><creator>He, Li-xin</creator><creator>Sheng, Zhi-yong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20111101</creationdate><title>Reduction of plasma gelsolin levels correlates with development of multiple organ dysfunction syndrome and fatal outcome in burn patients</title><author>Huang, Li-feng ; Yao, Yong-ming ; Li, Jin-feng ; Dong, Ning ; Liu, Chen ; Yu, Yan ; He, Li-xin ; Sheng, Zhi-yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c761t-222ebcdd457e1e638f3352e1d15d19f4a5ffc1c783917a67342801c9e95ffef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acids</topic><topic>Actin</topic><topic>Adult</topic><topic>Analysis</topic><topic>Binding proteins</topic><topic>Biology</topic><topic>Blood</topic><topic>Burn patients</topic><topic>Burns</topic><topic>Burns - blood</topic><topic>Burns - complications</topic><topic>Case-Control Studies</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gelsolin</topic><topic>Gelsolin - blood</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunology</topic><topic>Interferon</topic><topic>Interleukin 2</topic><topic>Interleukin 4</topic><topic>Interleukin-2 - blood</topic><topic>Interleukin-4 - blood</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Multiple organ dysfunction syndrome</topic><topic>Multiple Organ Failure - blood</topic><topic>Multiple Organ Failure - etiology</topic><topic>Multiple Organ Failure - mortality</topic><topic>Muscle proteins</topic><topic>Musculoskeletal system</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Peripheral blood</topic><topic>Permeability</topic><topic>Plasma</topic><topic>Prognosis</topic><topic>Protein binding</topic><topic>Proteins</topic><topic>Reduction</topic><topic>Regression analysis</topic><topic>Rodents</topic><topic>Sepsis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>T cells</topic><topic>T-Lymphocytes - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Li-feng</au><au>Yao, Yong-ming</au><au>Li, Jin-feng</au><au>Dong, Ning</au><au>Liu, Chen</au><au>Yu, Yan</au><au>He, Li-xin</au><au>Sheng, Zhi-yong</au><au>Egles, Christophe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of plasma gelsolin levels correlates with development of multiple organ dysfunction syndrome and fatal outcome in burn patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>6</volume><issue>11</issue><spage>e25748</spage><epage>e25748</epage><pages>e25748-e25748</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in critically ill surgical patients. We hypothesized that the extent of pGSN reduction might correlate with different outcome of burn patients. The study was performed to evaluate the prognostic implications of pGSN levels on the development of multiple organ dysfunction syndrome (MODS) and fatal outcome in a group of severely burn patients.
95 patients were included, and they were divided into three groups with different burn area: group I (n = 33), group II (n = 32) and group III (n = 30). According to whether there was development of MODS or not, patients were divided into MODS group (n = 28) and none-MODS group (n = 67); then the patients with MODS were further divided into non-survivor group (n = 17) and survivor group (n = 11). The peripheral blood samples were collected on postburn days (PBD) 1, 3, 7, 14, and 21. The levels of pGSN were determined and T cells were procured from the blood. The contents of cytokines (IL-2, IL-4 and IFN-γ) released by T cells were also measured. The related factors of prognosis were analyzed by using multivariate logistic regression analysis. The results showed that pGSN concentrations, as well as the levels of IL-2 and IFN-γ, decreased markedly on PBD 1-21, whereas, the levels of IL-4 increased markedly in all burn groups as compared with normal controls (P<0.05 or P<0.01), and there were obviously differences between group I and group III (P<0.05 or P<0.01). The similar results were found in MODS patients and the non-survivor group as compared with those without MODS and the survival group on days 3-21 postburn (P<0.05 or P<0.01). Moreover, as the pGSN levels decreased, the incidence of septic complication as well as MODS remarkably increased.
pGSN levels appear to be an early prognostic marker in patients suffering from major burns.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22069445</pmid><doi>10.1371/journal.pone.0025748</doi><tpages>e25748</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1310775831 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acids Actin Adult Analysis Binding proteins Biology Blood Burn patients Burns Burns - blood Burns - complications Case-Control Studies Cytokines Dendritic cells Enzyme-Linked Immunosorbent Assay Female Gelsolin Gelsolin - blood Hospitals Humans Immunology Interferon Interleukin 2 Interleukin 4 Interleukin-2 - blood Interleukin-4 - blood Lymphocytes Lymphocytes T Male Medical research Medicine Metabolism Mortality Multiple organ dysfunction syndrome Multiple Organ Failure - blood Multiple Organ Failure - etiology Multiple Organ Failure - mortality Muscle proteins Musculoskeletal system Patient outcomes Patients Peripheral blood Permeability Plasma Prognosis Protein binding Proteins Reduction Regression analysis Rodents Sepsis Studies Surgery Survival Rate T cells T-Lymphocytes - metabolism Trauma γ-Interferon |
| title | Reduction of plasma gelsolin levels correlates with development of multiple organ dysfunction syndrome and fatal outcome in burn patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T04%3A47%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduction%20of%20plasma%20gelsolin%20levels%20correlates%20with%20development%20of%20multiple%20organ%20dysfunction%20syndrome%20and%20fatal%20outcome%20in%20burn%20patients&rft.jtitle=PloS%20one&rft.au=Huang,%20Li-feng&rft.date=2011-11-01&rft.volume=6&rft.issue=11&rft.spage=e25748&rft.epage=e25748&rft.pages=e25748-e25748&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0025748&rft_dat=%3Cgale_plos_%3EA476863683%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1310775831&rft_id=info:pmid/22069445&rft_galeid=A476863683&rft_doaj_id=oai_doaj_org_article_cc2c54c4f32746398b139e8a8c55381a&rfr_iscdi=true |