Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts

Inflammation is one of main mechanisms of autoimmune disorders and a common feature of most diseases. Appropriate suppression of inflammation is a key resolution to treat the diseases. Sirtuin1 (Sirt1) has been shown to play a role in regulation of inflammation. Resveratrol, a potent Sirt1 activator...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27081
Hauptverfasser:	Zhu, Xiaoxia, Liu, Qiong, Wang, Meimei, Liang, Minrui, Yang, Xue, Xu, Xue, Zou, Hejian, Qiu, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Anti-Inflammatory Agents Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Arthritis Autoimmune diseases Biology Blotting, Western Cell Line Cell Proliferation Chemistry Cytokines Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gelatinase B Gene expression Hospitals Immunoglobulins Immunology Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Inflammation Mediators Interleukin 6 Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Ischemia Kinases Ligands Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Medical treatment Medicine Metabolism Mice Neutrophils NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Phosphorylation Proteins Rapamycin Real-Time Polymerase Chain Reaction RelA protein Resveratrol Rheumatology Ribonucleic acid RNA RNA, Messenger - genetics RNA, Small Interfering - genetics RNA-mediated interference Rodents Sepsis SIRT1 protein Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - genetics Sirtuin 1 - metabolism Stilbenes - pharmacology TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - toxicity Tumor necrosis factor-α
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