Optimal antiviral switching to minimize resistance risk in HIV therapy

The development of resistant strains of HIV is the most significant barrier to effective long-term treatment of HIV infection. The most common causes of resistance development are patient noncompliance and pre-existence of resistant strains. In this paper, methods of antiviral regimen switching are...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27047-e27047
Hauptverfasser:	Luo, Rutao, Piovoso, Michael J, Martinez-Picado, Javier, Zurakowski, Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Anti-HIV Agents - therapeutic use Antiretroviral drugs Antiviral agents Antiviral drugs Biology Care and treatment Cell death Computer engineering Control methods Drug Resistance, Viral Engineering Failure Health aspects Health risks HIV HIV - drug effects HIV - genetics HIV infections HIV Infections - drug therapy HIV Infections - virology Human immunodeficiency virus Humans Infection control Mathematical models Mathematics Medicine Mutation Optimal control Patient compliance Risk Risk factors Risk reduction Statistical analysis Statistical models Strains (organisms) Switches Switching Therapy Viral Load Viruses
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