Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells

We previously reported that a bi-phasic innate immune MAPK response, constituting activation of the mitogen-activated protein kinase (MAPK) phosphatase MKP1 and c-Fos transcription factor, discriminates between the yeast and hyphal forms of Candida albicans in oral epithelial cells (ECs). Since the...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e26580-e26580
Hauptverfasser:	Moyes, David L, Murciano, Celia, Runglall, Manohursingh, Islam, Ayesha, Thavaraj, Selvam, Naglik, Julian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal agents Biology c-Fos protein c-Jun protein Candida albicans Candida albicans - immunology CCL20 protein Chemokine CCL20 Cytokines Dendritic cells Epithelial cells Epithelial Cells - metabolism Epithelial Cells - microbiology Female Fungal infections Granulocyte Colony-Stimulating Factor Health aspects Humans Hyphae Hyphae - immunology Immune response Immune system Immunity, Innate Immunoglobulins Immunology Infection Inflammation Innate immunity Interleukin 6 Kinases Laboratories Low level MAP kinase MAP kinase phosphatase MAP Kinase Signaling System - immunology Medical research Medicine Mouth Mucosa - immunology Mouth Mucosa - microbiology Mucosa NF-kappa B - immunology NF-κB protein Pathology Pathways Phosphatase Phosphatases Protein kinase Protein kinases Proteins Signal transduction Signaling Tissues Transcription activation Transcription factors Trends Vagina Vagina - immunology Vagina - microbiology Vagina - pathology Yeast
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