γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo

γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation induces de novo protein synthesis and enhances antigen presentation, we therefore investigated whether γ-radiation results in increased expression...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e28217
Hauptverfasser:	Sharma, Anu, Bode, Beata, Wenger, Roland H, Lehmann, Kuno, Sartori, Alessandro A, Moch, Holger, Knuth, Alexander, Boehmer, Lotta von, Broek, Maries van den
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antigen (tumor-associated) Antigen presentation Antigens Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Ataxia Telangiectasia Mutated Proteins Background radiation Biopsy Biotechnology Bone cancer Breast cancer Cancer Cancer therapies CD8 antigen Cell cycle Cell Cycle Proteins - metabolism Cell Line, Tumor Cytotoxicity DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - metabolism Female Fibroblasts Gamma Rays Gene expression Gene Expression Regulation, Neoplastic - radiation effects Genotoxicity Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Hyperthermia Hypoxia Immunity Immunology Immunotherapy Infiltration Irradiation Kinases Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - radiation effects Major histocompatibility complex Male Medical research Medicine Melanoma Metastases Multiple myeloma Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Nuclear Proteins - metabolism Oncology Patients Protein biosynthesis Protein synthesis Protein-Serine-Threonine Kinases - metabolism Radiation Radiation therapy Recognition RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sarcoma Signal Transduction - radiation effects Stress Stress, Physiological - radiation effects Stresses T-Lymphocytes - immunology T-Lymphocytes - radiation effects Tumor cell lines Tumor cells Tumor Suppressor Proteins - metabolism Tumors Up-Regulation - radiation effects γ Radiation
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