Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress

Master regulator protein p53, popularly known as the "guardian of genome" is the hub for regulation of diverse cellular pathways. Depending on the cell type and severity of DNA damage, p53 protein mediates cell cycle arrest or apoptosis, besides activating DNA repair, which is apparently a...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e26156
Hauptverfasser:	Bansal, Nidhi, Kadamb, Rama, Mittal, Shilpi, Vig, Leena, Sharma, Raisha, Dwarakanath, Bilikere S, Saluja, Daman
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Anthracyclines Apoptosis Biology Biomedical research Cell cycle Cell Cycle Proteins - genetics Cell Line, Tumor Cell lines Chromatin Chromatin remodeling Deoxyribonucleic acid DNA DNA binding proteins DNA Damage DNA methylation DNA repair Down-Regulation - drug effects Doxorubicin - pharmacology Experiments Gene expression Gene regulation Gene silencing Gene Silencing - drug effects Genes Genomes Genotoxicity Heat shock proteins Histone deacetylase Histone Deacetylase 1 - metabolism Histones - chemistry Histones - metabolism HSC70 Heat-Shock Proteins - genetics Humans Immunoglobulins Kinases Leukemia Lysine - metabolism Methylation Methylation - drug effects Mice Nuclear Proteins - genetics p53 Protein Phosphorylation Phosphorylation - drug effects Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Promoters Protein interaction Protein Structure, Tertiary Protein-protein interactions Proteins Recruitment Repressor Proteins - chemistry Repressor Proteins - metabolism Stresses Transcription (Genetics) Transcription factors Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Tumor suppressor proteins Tumors zeta-Crystallins - genetics
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