PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response

The ability of the intestinal epithelial barrier to respond to various injurious insults is an essential component of intestinal homeostasis. However, the molecular mechanisms responsible for wound-healing and repair in the intestine are poorly understood. The glycogen synthase kinase 3ß (GSK3ß) has...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e26340-e26340
Hauptverfasser:	Karrasch, Thomas, Spaeth, Tanja, Allard, Brigitte, Jobin, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Accumulation AKT protein Animals Antibodies Base Sequence beta Catenin - metabolism Biological activity Biology Blocking Blotting, Western c-Myc protein Catenin Cell adhesion & migration Cell culture Cell Line Cell migration Cell spreading Colorectal cancer Crohn's disease Crohns disease Cytokines DNA Primers Drug dosages Embryo fibroblasts Embryos Epithelial cells Experiments Fibroblasts Gene expression Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - chemistry Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Glycogen synthesis Homeostasis Inflammation Inflammatory bowel disease Internal medicine Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Intestine Kinases LEF protein Medicine Mice Mice, Knockout Molecular modelling Myc protein NF-κB protein Nuclear transport Pathogenesis Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Polymerase chain reaction Protein Transport Rats Real-Time Polymerase Chain Reaction Restitution RNA Rodents Scraping Serine - metabolism Signal Transduction Signaling Transcription Transcription (Genetics) Translocation Wound Healing
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