The microRNA-processing enzyme Dicer is essential for thyroid function

Dicer is a type III ribonuclease required for the biogenesis of microRNAs (miRNAs), a class of small non-coding RNAs regulating gene expression at the post-transcriptional level. To explore the functional role of miRNAs in thyroid gland function, we generated a thyrocyte-specific Dicer conditional k...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27648-e27648
Hauptverfasser:	Frezzetti, Daniela, Reale, Carla, Calì, Gaetano, Nitsch, Lucio, Fagman, Henrik, Nilsson, Ola, Scarfò, Marzia, De Vita, Gabriella, Di Lauro, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Animals Animals, Newborn Biology Biomarkers - metabolism Biosynthesis Body weight Cancer Cancer and Oncology Cancer och onkologi Cell Adhesion Molecules - metabolism Cell and Molecular Biology Cell Differentiation Cell- och molekylärbiologi Congenital diseases Deregulation Differentiation Embryo, Mammalian - enzymology Embryo, Mammalian - pathology Endocrinology Enzyme Activation Enzymes Fluorescent Antibody Technique Gene expression Genes Genetic aspects Hormones Humans Hypothyroidism Hypothyroidism - enzymology Hypothyroidism - pathology Life span Machinery and equipment Medicine Metastasis Mice Mice, Knockout MicroRNA MicroRNAs MicroRNAs - metabolism miRNA Morphogenesis Oxyphil Cells - metabolism Oxyphil Cells - pathology Post-transcription Ribonuclease Ribonuclease III Ribonuclease III - metabolism Ribonucleic acid RNA RNA Processing, Post-Transcriptional Stem cells Thyroid Thyroid gland Thyroid Gland - enzymology Thyroid Gland - growth & development Thyroid Gland - pathology Thyroid hormones Transcription (Genetics) Transcription factors Weight reduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!