The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis

Protein ubiquitination is a post-translational protein modification that regulates many biological conditions. Trip12 is a HECT-type E3 ubiquitin ligase that ubiquitinates ARF and APP-BP1. However, the significance of Trip12 in vivo is largely unknown. Here we show that the ubiquitin ligase activity...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e25871-e25871
Hauptverfasser:	Kajiro, Masashi, Tsuchiya, Mai, Kawabe, Yoh-Ichi, Furumai, Ryohei, Iwasaki, Naoya, Hayashi, Yuki, Katano, Miyuki, Nakajima, Yuka, Goto, Natsuka, Watanabe, Tatsuya, Murayama, Akiko, Oishi, Hisashi, Ema, Masatsugu, Takahashi, Satoru, Kishimoto, Hiroyuki, Yanagisawa, Junn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bioinformatics Biology Cancer Cell cycle Cell Cycle - genetics Cell proliferation Chromatin Chromatin remodeling Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism Cloning Cyclin-Dependent Kinase Inhibitor p16 - metabolism Developmental stages Embryo, Mammalian - metabolism Embryogenesis Embryology Embryonic development Embryonic Development - genetics Embryonic growth stage Embryonic Stem Cells - metabolism Embryos Environmental science Enzymes Female Gene expression Genes Lethality Ligases Male Mice Mutation Phenotype Post-translation Protein Stability Protein Structure, Tertiary Proteins Thyroid gland Transcriptome Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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