The role of kinin receptors in preventing neuroinflammation and its clinical severity during experimental autoimmune encephalomyelitis in mice

Multiple sclerosis (MS) is a demyelinating and neuroinflammatory disease of the human central nervous system (CNS). The expression of kinins is increased in MS patients, but the underlying mechanisms by which the kinin receptor regulates MS development have not been elucidated. Experimental autoimmu...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27875
Hauptverfasser:	Dutra, Rafael C, Leite, Daniela F P, Bento, Allisson F, Manjavachi, Marianne N, Patrício, Eliziane S, Figueiredo, Cláudia P, Pesquero, João B, Calixto, João B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Blood-brain barrier Bradykinin Receptor Antagonists Brain cancer CD4-Positive T-Lymphocytes - immunology Central nervous system Chronic Disease Chronic illnesses Cytokines Cytokines - biosynthesis Demyelination Disease Disease Models, Animal Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - complications Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Female Freund's adjuvant Gene Deletion Gene expression Glial cells Helper cells House mouse Humans Immune response Immune system Immunization Inflammation Inflammation - complications Inflammation - pathology Inflammation - prevention & control Inflammatory bowel disease Kinins Lymphocytes Lymphocytes T Lymphoid Tissue - immunology Lymphoid Tissue - pathology Medicine Membrane permeability Mice Mice, Inbred C57BL Models, Biological Multiple sclerosis Myelin Sheath - metabolism Nervous system diseases Oxidative stress Peripheral neuropathy Permeability Pertussis Pertussis toxin Pharmacology Prevention Receptors Receptors, Bradykinin - metabolism Rodents Smooth muscle Spinal Cord - metabolism Spinal Cord - pathology Th1 Cells - immunology Th17 Cells - immunology Toxins Transcription factors Tumors Whooping cough
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