Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies

Atopic dermatitis (AD) is a common inflammatory skin disease caused by multiple genetic and environmental factors. AD is characterized by the local infiltration of T helper type 2 (Th2) cells. Recent clinical studies have shown important roles of the Th2 chemokines, CCL22 and CCL17 in the pathogenes...

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Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e26987-e26987
Hauptverfasser:	Hirota, Tomomitsu, Saeki, Hidehisa, Tomita, Kaori, Tanaka, Shota, Ebe, Kouji, Sakashita, Masafumi, Yamada, Takechiyo, Fujieda, Shigeharu, Miyatake, Akihiko, Doi, Satoru, Enomoto, Tadao, Hizawa, Nobuyuki, Sakamoto, Tohru, Masuko, Hironori, Sasaki, Takashi, Ebihara, Tamotsu, Amagai, Masayuki, Esaki, Hitokazu, Takeuchi, Satoshi, Furue, Masutaka, Noguchi, Emiko, Kamatani, Naoyuki, Nakamura, Yusuke, Kubo, Michiaki, Tamari, Mayumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advertising executives Alleles Allergies Analysis Asian Continental Ancestry Group - genetics Asthma Atopic dermatitis Biology Case-Control Studies CCL17 protein CCL22 protein Chemokine CCL22 - genetics Chemokine CCL22 - metabolism Chemokines Clinical medicine Dendritic cells Deoxyribonucleic acid Dermatitis Dermatitis, Atopic - ethnology Dermatitis, Atopic - genetics Dermatitis, Atopic - metabolism Dermatology Development and progression Disease control Disease susceptibility DNA Eczema Electrophoretic mobility Electrophoretic Mobility Shift Assay Environmental factors Etiology Female Functional analysis Gene Expression Gene Frequency Genes Genetic aspects Genetic Predisposition to Disease - genetics Genomes Genotype Helper cells Humans Infiltration Inflammation Japan Kawasaki disease Laboratories Linkage Disequilibrium Lymphocytes T Male Medical research Medicine Middle Aged mRNA Nuclear Proteins - metabolism Otolaryngology Pathogenesis Polymorphism, Single Nucleotide Protein Binding Proteins Psoriasis Respiratory diseases Rheumatoid arthritis Risk analysis RNA Science Single nucleotide polymorphisms Single-nucleotide polymorphism Skin Skin diseases Studies Surgery Young Adult
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