Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury

Renal ischemia-reperfusion (IR) injury (IRI) is a common and important trigger of acute renal injury (AKI). It is inevitably linked to transplantation. Involving both, the innate and the adaptive immune response, IRI causes subsequent sterile inflammation. Attraction to and transmigration of immune...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e26419-e26419
Hauptverfasser:	Kentrup, Dominik, Reuter, Stefan, Schnöckel, Uta, Grabner, Alexander, Edemir, Bayram, Pavenstädt, Hermann, Schober, Otmar, Schäfers, Michael, Schlatter, Eberhard, Büssemaker, Eckhart
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use Abdomen Adaptive immunity Animals Apoptosis Biology Blood-brain barrier Blotting, Western Bone marrow Cell adhesion & migration Creatinine Cytoskeleton Emission analysis Epithelial cells Fluorides Histology Hypertension Hypoxia Immune response Immune system Immunohistochemistry Inhibition Injuries Intensive care Internal medicine Ischemia Kidney - drug effects Kidney - metabolism Kidney diseases Male Medicine Nephrology Neutrophils Nuclear medicine Osmolarity Perfusion Permeability Polymerase Chain Reaction Polyuria Positron emission Positron emission tomography Protein kinase Protein kinases Proteins Proteinuria Rats Rats, Sprague-Dawley Renal function Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Rodents Stratigraphy Stroke Tomography Transplantation Transplants & implants Urea Urine Veins & arteries
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