Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling

Generation of hepatocyte from embryonic stem cells (ESCs) holds great promise for hepatocyte replacement therapy to treat liver diseases. Achieving high efficiency of directed differentiation of ESCs to hepatocyte is of critical importance. Previously, Wnt3a has been reported to promote Activin A-in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-11, Vol.6 (11), p.e27965
Hauptverfasser:	Fu, Shijun, Fei, Qi, Jiang, Hua, Chuai, Shannon, Shi, Song, Xiong, Wen, Jiang, Lei, Lu, Chris, Atadja, Peter, Li, En, Shou, Jianyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetylation Acetylation - drug effects Activin Activins - pharmacology Analysis Animals Biological activity Biology Biomarkers - metabolism Biomedical research Cell differentiation Cell Differentiation - drug effects Cell Differentiation - genetics Cell growth Cellular biology Chromatin Differentiation (biology) Embryo cells Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Endoderm Endoderm - cytology Endoderm - drug effects Endoderm - enzymology Epigenetic inheritance Epigenetics Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental - drug effects Genomes Genomics Growth factors Hepatocyte Nuclear Factor 3-beta - genetics Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Histone deacetylase Histone Deacetylases - metabolism Histones - metabolism HMGB Proteins - genetics Humans Hydroxamic Acids - pharmacology Liver Liver cancer Liver diseases Mice MicroRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular modelling Promoter Regions, Genetic - genetics R&D Regulations Research & development Ribonucleic acid RNA Signal Transduction - drug effects SOXF Transcription Factors - genetics Stem cell transplantation Stem cells Wnt3A Protein - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!