Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium

Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must transfect the airway epithelium efficiently and not cause inflammation so they are suitable for repeated dosing. The inhaled aerosol should be depo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e26768
Hauptverfasser:	Manunta, Maria D I, McAnulty, Robin J, Tagalakis, Aristides D, Bottoms, Stephen E, Campbell, Frederick, Hailes, Helen C, Tabor, Alethea B, Laurent, Geoffrey J, O'Callaghan, Christopher, Hart, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerodynamic properties Aerodynamics Aerosol deposition Aerosols Biology Care and treatment Cations Chemistry Childrens health Cystic fibrosis Cystic Fibrosis - therapy Densitometers Densitometry Deoxyribonucleic acid Deposition DNA E coli Efficiency Electrostatic properties Epithelium Epithelium - metabolism Expression vectors Gel electrophoresis Gene expression Gene therapy Gene transfer Gene Transfer Techniques Genes Genetic Therapy - methods Genetic vectors Glands Health aspects Inflammation Lipids Liposomes Lung diseases Lungs Medical treatment Medicine Molecular Targeted Therapy Nanocomposites - administration & dosage Nebulizers and Vaporizers Peptides Plasmids Plasmids - administration & dosage Respiratory Mucosa - metabolism Respiratory tract Surface charge Therapeutic applications Transfection Vectors (Biology) Viral genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!