Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload

Activating transcription factor 3 (ATF3), which is encoded by an adaptive-response gene induced by various stimuli, plays an important role in the cardiovascular system. However, the effect of ATF3 on cardiac hypertrophy induced by a pathological stimulus has not been determined. Here, we investigat...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e26744-e26744
Hauptverfasser:	Zhou, Heng, Shen, Di-Fei, Bian, Zhou-Yan, Zong, Jing, Deng, Wei, Zhang, Yan, Guo, Yuan-Yuan, Li, Hongliang, Tang, Qi-Zhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Activating Transcription Factor 3 - deficiency Activating Transcription Factor 3 - metabolism Angiotensin Angiotensin II Animal models Animals Aorta Apoptosis Banding Biology Cardiology Cardiomegaly - complications Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - physiopathology Cardiomyocytes Cardiomyopathy, Dilated - complications Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - pathology Cardiomyopathy, Dilated - physiopathology Cardiovascular system Cell growth Cytotoxicity Deoxyribonucleic acid Disease Models, Animal DNA Extracellular Signal-Regulated MAP Kinases - metabolism Fibrosis Gene expression Genes Heart Heart diseases Heart hypertrophy Heat shock proteins Hemodynamics Humans Hypertrophy Ischemia JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases Laboratory animals Male MAP Kinase Signaling System Medicine Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase Kinases - metabolism Myocardium - enzymology Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Neonates Neurosciences Pathways Rodents Signaling Transcription factors Tumorigenesis Ventricular Pressure
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