Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway

Stress-inducible transcription factors play a pivotal role in cellular adaptation to environment to maintain homeostasis and integrity of the genome. Activating transcription factor 3 (ATF3) is induced by a variety of stress and inflammatory conditions and is over-expressed in many kinds of cancer c...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e26848-e26848
Hauptverfasser:	Tanaka, Yujiro, Nakamura, Aya, Morioka, Masaki Suimye, Inoue, Shoko, Tamamori-Adachi, Mimi, Yamada, Kazuhiko, Taketani, Kenji, Kawauchi, Junya, Tanaka-Okamoto, Miki, Miyoshi, Jun, Tanaka, Hiroshi, Kitajima, Shigetaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Activating Transcription Factor 3 - genetics Alkylation Apoptosis Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Binding sites Bioinformatics Biology Calcium Calcium signalling Cancer Cancer genetics Cell adhesion Cell cycle Cell Line, Tumor Colorectal cancer Deoxyribonucleic acid Diabetes mellitus DNA DNA binding proteins DNA damage DNA Damage - genetics DNA repair Gene expression Gene regulation Gene Regulatory Networks Genes Genetic aspects Genetics Genomes Genomics Growth factors Homeostasis Humans Hypoxia Inflammation Insulin Kinases Laboratories Male Medical research Metabolic pathways Methyl methanesulfonate Molecular biology Molecular modelling Neoplasms - genetics Neoplasms - metabolism Oxidative Stress - genetics p53 Protein Prostate Prostate cancer Science Signal transduction Stress Stress response Stresses Systems analysis Target recognition Transcription (Genetics) Transcription factors Transcription Factors - genetics Tumor proteins Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors Vascular endothelial growth factor Wnt protein
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