Pathobiological implications of MUC16 expression in pancreatic cancer

MUC16 (CA125) belongs to a family of high-molecular weight O-glycosylated proteins known as mucins. While MUC16 is well known as a biomarker in ovarian cancer, its expression pattern in pancreatic cancer (PC), the fourth leading cause of cancer related deaths in the United States, remains unknown. T...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e26839
Hauptverfasser:	Haridas, Dhanya, Chakraborty, Subhankar, Ponnusamy, Moorthy P, Lakshmanan, Imayavaramban, Rachagani, Satyanarayana, Cruz, Eric, Kumar, Sushil, Das, Srustidhar, Lele, Subodh M, Anderson, Judy M, Wittel, Uwe A, Hollingsworth, Michael A, Batra, Surinder K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Analysis Biochemistry Biology Biomarkers Biotechnology Blotting, Western CA-125 Antigen - genetics CA-125 Antigen - metabolism Cancer Cancer metastasis Cancer research Cancer therapies Cell growth Cell Line, Tumor Deoxyribonucleic acid Development and progression DNA DNA methylation Extracellular matrix Gene expression Gene Expression Regulation, Neoplastic Health aspects Humans Immunohistochemistry Invasiveness Lesions Liver Lungs Lymph nodes Medical imaging Medical prognosis Medicine Membrane Proteins - genetics Membrane Proteins - metabolism Metastases Metastasis Microscopy, Confocal Molecular biology Molecular weight mRNA Mucin Mucins Neoplasm Metastasis Omentum Ovarian cancer Ovarian carcinoma Pancreatic cancer Pancreatic Ducts - metabolism Pancreatic Ducts - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatitis Pathology Patients Polymerase chain reaction Prognosis Proteins Quality Reverse Transcriptase Polymerase Chain Reaction RNA Tissues Tomography
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