Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53

Genotoxic stressors, such as radiation, induce cellular damage that activates pre-programmed repair pathways, some of which involve microRNAs (miRNA) that alter gene expression. The let-7 family of miRNA regulates multiple cellular processes including cell division and DNA repair pathways. However,...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e24429-e24429
Hauptverfasser:	Saleh, Anthony D, Savage, Jason E, Cao, Liu, Soule, Benjamin P, Ly, David, DeGraff, William, Harris, Curtis C, Mitchell, James B, Simone, Nicole L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal tissues Animals Anticancer properties Antitumor agents Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Ataxia Telangiectasia Mutated Proteins bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Binding sites Biocompatibility Biology Cancer therapies Cell cycle Cell Cycle Proteins - metabolism Cell division Cell growth Cellular stress response Chromatin Colon Colon cancer Colorectal cancer Cytotoxicity Deoxyribonucleic acid Development and progression DNA DNA Damage DNA methylation DNA repair DNA-Binding Proteins - metabolism Enhancer Elements, Genetic - genetics Exposure Fibroblasts Gene expression Gene Expression Regulation, Neoplastic - radiation effects Gene regulation Genomics Genotoxicity HCT116 Cells Head & neck cancer Humans Immunoprecipitation Ionizing radiation Laboratories Luciferase Medicine Mice Mice, Inbred C57BL MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Oncology Ovarian cancer Oxidative Stress - genetics Oxidative Stress - radiation effects p53 Protein Penicillin Phosphorylation Phosphorylation - radiation effects Protein Binding - radiation effects Protein-Serine-Threonine Kinases - metabolism Proteins Radiation Radiation damage Radiation effects Radiation therapy Repair Ribonucleic acid RNA Signaling Stresses Thyroid gland Toxicity Transcription, Genetic - radiation effects Tumor proteins Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ultraviolet Rays
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