Foxf2: a novel locus for anterior segment dysgenesis adjacent to the Foxc1 gene
Anterior segment dysgenesis (ASD) is characterised by an abnormal migration of neural crest cells or an aberrant differentiation of the mesenchymal cells during the formation of the eye's anterior segment. These abnormalities result in multiple tissue defects affecting the iris, cornea and drai...
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| description | Anterior segment dysgenesis (ASD) is characterised by an abnormal migration of neural crest cells or an aberrant differentiation of the mesenchymal cells during the formation of the eye's anterior segment. These abnormalities result in multiple tissue defects affecting the iris, cornea and drainage structures of the iridocorneal angle including the ciliary body, trabecular meshwork and Schlemm's canal. In some cases, abnormal ASD development leads to glaucoma, which is usually associated with increased intraocular pressure. Haploinsufficiency through mutation or chromosomal deletion of the human FOXC1 transcription factor gene or duplications of the 6p25 region is associated with a spectrum of ocular abnormalities including ASD. However, mapping data and phenotype analysis of human deletions suggests that an additional locus for this condition may be present in the same chromosomal region as FOXC1. DHPLC screening of ENU mutagenised mouse archival tissue revealed five novel mouse Foxf2 mutations. Re-derivation of one of these (the Foxf2(W174R) mouse lineage) resulted in heterozygote mice that exhibited thinning of the iris stroma, hyperplasia of the trabecular meshwork, small or absent Schlemm's canal and a reduction in the iridocorneal angle. Homozygous E18.5 mice showed absence of ciliary body projections, demonstrating a critical role for Foxf2 in the developing eye. These data provide evidence that the Foxf2 gene, separated from Foxc1 by less than 70 kb of genomic sequence (250 kb in human DNA), may explain human abnormalities in some cases of ASD where FOXC1 has been excluded genetically. |
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These abnormalities result in multiple tissue defects affecting the iris, cornea and drainage structures of the iridocorneal angle including the ciliary body, trabecular meshwork and Schlemm's canal. In some cases, abnormal ASD development leads to glaucoma, which is usually associated with increased intraocular pressure. Haploinsufficiency through mutation or chromosomal deletion of the human FOXC1 transcription factor gene or duplications of the 6p25 region is associated with a spectrum of ocular abnormalities including ASD. However, mapping data and phenotype analysis of human deletions suggests that an additional locus for this condition may be present in the same chromosomal region as FOXC1. DHPLC screening of ENU mutagenised mouse archival tissue revealed five novel mouse Foxf2 mutations. Re-derivation of one of these (the Foxf2(W174R) mouse lineage) resulted in heterozygote mice that exhibited thinning of the iris stroma, hyperplasia of the trabecular meshwork, small or absent Schlemm's canal and a reduction in the iridocorneal angle. Homozygous E18.5 mice showed absence of ciliary body projections, demonstrating a critical role for Foxf2 in the developing eye. These data provide evidence that the Foxf2 gene, separated from Foxc1 by less than 70 kb of genomic sequence (250 kb in human DNA), may explain human abnormalities in some cases of ASD where FOXC1 has been excluded genetically.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0025489</identifier><identifier>PMID: 22022403</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aberration ; Abnormalities ; Aging - pathology ; Amino Acid Sequence ; Amino acids ; Analysis ; Animals ; Anterior segment dysgenesis syndrome ; Archives & records ; Base Sequence ; Biological Specimen Banks ; Biology ; Chromatography ; Chromosome deletion ; Clonal deletion ; Cornea ; Cornea - pathology ; Data processing ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Embryo, Mammalian - abnormalities ; Embryo, Mammalian - pathology ; Ethyl nitrosourea ; Ethylnitrosourea ; Eye ; Eye Abnormalities - genetics ; Eye Abnormalities - pathology ; Eye diseases ; Forkhead Transcription Factors - chemistry ; Forkhead Transcription Factors - genetics ; FOXC1 gene ; Gene deletion ; Gene mapping ; Genes ; Genetic aspects ; Genetic Loci - genetics ; Genotype & phenotype ; Glaucoma ; Haploinsufficiency ; Homozygote ; Hyperplasia ; Intraocular pressure ; Iris ; Iris - pathology ; Loci ; Lymphedema ; Medicine ; Mesenchyme ; Mice ; Molecular Sequence Data ; Morphogenesis ; Mutation ; Mutation - genetics ; Neural crest ; Nucleotide sequence ; Phenotype ; Phylogeny ; Proteins ; Retina ; Stroma ; Topography ; Transcription (Genetics) ; Transcription factors</subject><ispartof>PloS one, 2011-10, Vol.6 (10), p.e25489</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 McKeone et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>McKeone et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-a84d684ed055f86831333c26c87a63f4939d6f7643e29602a3b9c2e2cd657faf3</citedby><cites>FETCH-LOGICAL-c691t-a84d684ed055f86831333c26c87a63f4939d6f7643e29602a3b9c2e2cd657faf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192754/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192754/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22022403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Veitia, Reiner Albert</contributor><creatorcontrib>McKeone, Richard</creatorcontrib><creatorcontrib>Vieira, Helena</creatorcontrib><creatorcontrib>Gregory-Evans, Kevin</creatorcontrib><creatorcontrib>Gregory-Evans, Cheryl Y</creatorcontrib><creatorcontrib>Denny, Paul</creatorcontrib><title>Foxf2: a novel locus for anterior segment dysgenesis adjacent to the Foxc1 gene</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Anterior segment dysgenesis (ASD) is characterised by an abnormal migration of neural crest cells or an aberrant differentiation of the mesenchymal cells during the formation of the eye's anterior segment. These abnormalities result in multiple tissue defects affecting the iris, cornea and drainage structures of the iridocorneal angle including the ciliary body, trabecular meshwork and Schlemm's canal. In some cases, abnormal ASD development leads to glaucoma, which is usually associated with increased intraocular pressure. Haploinsufficiency through mutation or chromosomal deletion of the human FOXC1 transcription factor gene or duplications of the 6p25 region is associated with a spectrum of ocular abnormalities including ASD. However, mapping data and phenotype analysis of human deletions suggests that an additional locus for this condition may be present in the same chromosomal region as FOXC1. DHPLC screening of ENU mutagenised mouse archival tissue revealed five novel mouse Foxf2 mutations. Re-derivation of one of these (the Foxf2(W174R) mouse lineage) resulted in heterozygote mice that exhibited thinning of the iris stroma, hyperplasia of the trabecular meshwork, small or absent Schlemm's canal and a reduction in the iridocorneal angle. Homozygous E18.5 mice showed absence of ciliary body projections, demonstrating a critical role for Foxf2 in the developing eye. These data provide evidence that the Foxf2 gene, separated from Foxc1 by less than 70 kb of genomic sequence (250 kb in human DNA), may explain human abnormalities in some cases of ASD where FOXC1 has been excluded genetically.</description><subject>Aberration</subject><subject>Abnormalities</subject><subject>Aging - pathology</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Analysis</subject><subject>Animals</subject><subject>Anterior segment dysgenesis syndrome</subject><subject>Archives & records</subject><subject>Base Sequence</subject><subject>Biological Specimen Banks</subject><subject>Biology</subject><subject>Chromatography</subject><subject>Chromosome deletion</subject><subject>Clonal deletion</subject><subject>Cornea</subject><subject>Cornea - pathology</subject><subject>Data processing</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Embryo, Mammalian - abnormalities</subject><subject>Embryo, Mammalian - pathology</subject><subject>Ethyl nitrosourea</subject><subject>Ethylnitrosourea</subject><subject>Eye</subject><subject>Eye Abnormalities - genetics</subject><subject>Eye Abnormalities - pathology</subject><subject>Eye diseases</subject><subject>Forkhead Transcription Factors - chemistry</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>FOXC1 gene</subject><subject>Gene deletion</subject><subject>Gene mapping</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Loci - genetics</subject><subject>Genotype & phenotype</subject><subject>Glaucoma</subject><subject>Haploinsufficiency</subject><subject>Homozygote</subject><subject>Hyperplasia</subject><subject>Intraocular pressure</subject><subject>Iris</subject><subject>Iris - pathology</subject><subject>Loci</subject><subject>Lymphedema</subject><subject>Medicine</subject><subject>Mesenchyme</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Morphogenesis</subject><subject>Mutation</subject><subject>Mutation - genetics</subject><subject>Neural crest</subject><subject>Nucleotide sequence</subject><subject>Phenotype</subject><subject>Phylogeny</subject><subject>Proteins</subject><subject>Retina</subject><subject>Stroma</subject><subject>Topography</subject><subject>Transcription (Genetics)</subject><subject>Transcription factors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r2zAUhs3YWLtu_2BshsFgF8n0ZdnaxaCUdgsUAvu6FbJ85Cg4VibJpf33lRe3xLDB0IXE0XNeHb28WfYaoyWmJf64dYPvVbfcux6WCJGCVeJJdooFJQtOEH16dD7JXoSwRaigFefPsxNCECEM0dNsfeVuDfmUq7x3N9DlndNDyI3zueojeJsOAdod9DFv7kILPQQbctVslR5r0eVxA3kS0Tgfb19mz4zqArya9rPs59Xlj4uvi-v1l9XF-fVCc4HjQlWs4RWDBhWFqXhFMaVUE66rUnFqmKCi4abkjAIRHBFFa6EJEN3wojTK0LPs7UF337kgJy-CxBQJxgQucCJWB6Jxaiv33u6Uv5NOWfmn4HwrlY9WdyBrXOESEapwpViNiFBQa9BlyQmtS4qS1ufptaHeQTN-3atuJjq_6e1Gtu5GUixIWbAk8G4S8O73ACH-Y-SJalWayvbGJTG9s0HLc1by5BMXVaKWf6HSamBndUqDsak-a_gwa0hMhNvYqiEEufr-7f_Z9a85-_6I3YDq4ia4bojW9WEOsgOovQvBg3l0DiM5hvnBDTmGWU5hTm1vjl1_bHpIL70H6Sfthw</recordid><startdate>20111013</startdate><enddate>20111013</enddate><creator>McKeone, Richard</creator><creator>Vieira, Helena</creator><creator>Gregory-Evans, Kevin</creator><creator>Gregory-Evans, Cheryl Y</creator><creator>Denny, Paul</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20111013</creationdate><title>Foxf2: a novel locus for anterior segment dysgenesis adjacent to the Foxc1 gene</title><author>McKeone, Richard ; Vieira, Helena ; Gregory-Evans, Kevin ; Gregory-Evans, Cheryl Y ; Denny, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-a84d684ed055f86831333c26c87a63f4939d6f7643e29602a3b9c2e2cd657faf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aberration</topic><topic>Abnormalities</topic><topic>Aging - pathology</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Analysis</topic><topic>Animals</topic><topic>Anterior segment dysgenesis syndrome</topic><topic>Archives & records</topic><topic>Base Sequence</topic><topic>Biological Specimen Banks</topic><topic>Biology</topic><topic>Chromatography</topic><topic>Chromosome deletion</topic><topic>Clonal deletion</topic><topic>Cornea</topic><topic>Cornea - pathology</topic><topic>Data processing</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>Embryo, Mammalian - abnormalities</topic><topic>Embryo, Mammalian - pathology</topic><topic>Ethyl nitrosourea</topic><topic>Ethylnitrosourea</topic><topic>Eye</topic><topic>Eye Abnormalities - genetics</topic><topic>Eye Abnormalities - pathology</topic><topic>Eye diseases</topic><topic>Forkhead Transcription Factors - chemistry</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>FOXC1 gene</topic><topic>Gene deletion</topic><topic>Gene mapping</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Loci - genetics</topic><topic>Genotype & phenotype</topic><topic>Glaucoma</topic><topic>Haploinsufficiency</topic><topic>Homozygote</topic><topic>Hyperplasia</topic><topic>Intraocular pressure</topic><topic>Iris</topic><topic>Iris - pathology</topic><topic>Loci</topic><topic>Lymphedema</topic><topic>Medicine</topic><topic>Mesenchyme</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Morphogenesis</topic><topic>Mutation</topic><topic>Mutation - genetics</topic><topic>Neural crest</topic><topic>Nucleotide sequence</topic><topic>Phenotype</topic><topic>Phylogeny</topic><topic>Proteins</topic><topic>Retina</topic><topic>Stroma</topic><topic>Topography</topic><topic>Transcription (Genetics)</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKeone, Richard</creatorcontrib><creatorcontrib>Vieira, Helena</creatorcontrib><creatorcontrib>Gregory-Evans, Kevin</creatorcontrib><creatorcontrib>Gregory-Evans, Cheryl Y</creatorcontrib><creatorcontrib>Denny, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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These abnormalities result in multiple tissue defects affecting the iris, cornea and drainage structures of the iridocorneal angle including the ciliary body, trabecular meshwork and Schlemm's canal. In some cases, abnormal ASD development leads to glaucoma, which is usually associated with increased intraocular pressure. Haploinsufficiency through mutation or chromosomal deletion of the human FOXC1 transcription factor gene or duplications of the 6p25 region is associated with a spectrum of ocular abnormalities including ASD. However, mapping data and phenotype analysis of human deletions suggests that an additional locus for this condition may be present in the same chromosomal region as FOXC1. DHPLC screening of ENU mutagenised mouse archival tissue revealed five novel mouse Foxf2 mutations. Re-derivation of one of these (the Foxf2(W174R) mouse lineage) resulted in heterozygote mice that exhibited thinning of the iris stroma, hyperplasia of the trabecular meshwork, small or absent Schlemm's canal and a reduction in the iridocorneal angle. Homozygous E18.5 mice showed absence of ciliary body projections, demonstrating a critical role for Foxf2 in the developing eye. These data provide evidence that the Foxf2 gene, separated from Foxc1 by less than 70 kb of genomic sequence (250 kb in human DNA), may explain human abnormalities in some cases of ASD where FOXC1 has been excluded genetically.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22022403</pmid><doi>10.1371/journal.pone.0025489</doi><tpages>e25489</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aberration Abnormalities Aging - pathology Amino Acid Sequence Amino acids Analysis Animals Anterior segment dysgenesis syndrome Archives & records Base Sequence Biological Specimen Banks Biology Chromatography Chromosome deletion Clonal deletion Cornea Cornea - pathology Data processing Deoxyribonucleic acid DNA DNA - genetics Embryo, Mammalian - abnormalities Embryo, Mammalian - pathology Ethyl nitrosourea Ethylnitrosourea Eye Eye Abnormalities - genetics Eye Abnormalities - pathology Eye diseases Forkhead Transcription Factors - chemistry Forkhead Transcription Factors - genetics FOXC1 gene Gene deletion Gene mapping Genes Genetic aspects Genetic Loci - genetics Genotype & phenotype Glaucoma Haploinsufficiency Homozygote Hyperplasia Intraocular pressure Iris Iris - pathology Loci Lymphedema Medicine Mesenchyme Mice Molecular Sequence Data Morphogenesis Mutation Mutation - genetics Neural crest Nucleotide sequence Phenotype Phylogeny Proteins Retina Stroma Topography Transcription (Genetics) Transcription factors |
| title | Foxf2: a novel locus for anterior segment dysgenesis adjacent to the Foxc1 gene |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T04%3A52%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Foxf2:%20a%20novel%20locus%20for%20anterior%20segment%20dysgenesis%20adjacent%20to%20the%20Foxc1%20gene&rft.jtitle=PloS%20one&rft.au=McKeone,%20Richard&rft.date=2011-10-13&rft.volume=6&rft.issue=10&rft.spage=e25489&rft.pages=e25489-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0025489&rft_dat=%3Cgale_plos_%3EA476868698%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1309449151&rft_id=info:pmid/22022403&rft_galeid=A476868698&rft_doaj_id=oai_doaj_org_article_b1817023a18a4b029aebcec77623b730&rfr_iscdi=true |