Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria

RTS,S/AS01(E) is the lead candidate pre-erythrocytic malaria vaccine. In Phase IIb field trials the safety profile was acceptable and the efficacy was 53% (95%CI 31%-72%) for protecting children against clinical malaria caused by P. falciparum. We studied CS-specific T cell responses in order to ide...

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Veröffentlicht in:	PloS one 2011, Vol.6 (10), p.e25786
Hauptverfasser:	Olotu, Ally, Moris, Philippe, Mwacharo, Jedidah, Vekemans, Johan, Kimani, Domtila, Janssens, Michel, Kai, Oscar, Jongert, Erik, Lievens, Marc, Leach, Amanda, Villafana, Tonya, Savarese, Barbara, Marsh, Kevin, Cohen, Joe, Bejon, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibody Specificity - immunology Antigens CD4 antigen Child, Preschool Children Circumsporozoite protein Clinical trials Correlation Cytokines Enzyme-linked immunosorbent assay Enzymes Ethics Field study Health risks Hepatitis Humans Identification methods Infant Infections Interferon-gamma - biosynthesis Interferon-gamma - metabolism Interleukin 2 Interleukin-2 - biosynthesis Interleukin-2 - metabolism Intracellular Space - metabolism Lymphocytes Lymphocytes T Malaria Malaria - prevention & control Malaria Vaccines - adverse effects Malaria Vaccines - chemistry Malaria Vaccines - immunology Medical research Medicine Molecular Sequence Data Multivariable control Parasites Plasmodium falciparum Plasmodium falciparum - immunology Polymerase chain reaction Prostate cancer Proteins Protozoan Proteins - immunology Regression analysis Regression models Risk management Risk reduction T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Time Factors Tumor necrosis factor-α Vaccination Vaccination - adverse effects Vaccination - methods Vaccines Vaccines, Subunit - adverse effects Vaccines, Subunit - chemistry Vaccines, Subunit - immunology Vector-borne diseases Volunteers Whooping cough γ-Interferon
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