New insight into the molecular mechanisms of the biological effects of DNA minor groove binders

Bisbenzimides, or Hoechst 33258 (H258), and its derivative Hoechst 33342 (H342) are archetypal molecules for designing minor groove binders, and widely used as tools for staining DNA and analyzing side population cells. They are supravital DNA minor groove binders with AT selectivity. H342 and H258...

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Veröffentlicht in:	PloS one 2011-10, Vol.6 (10), p.e25822
Hauptverfasser:	Zhang, Xinbo, Zhang, Siyu Crystal, Sun, Dejun, Hu, Jiang, Wali, Anil, Pass, Harvey, Fernandez-Madrid, Felix, Harbut, Michael R, Tang, Naimei
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Apoptosis - drug effects Benzimidazoles - metabolism Benzimidazoles - pharmacology Binders Bioinformatics Biological effects Biology Biopharmaceuticals Bisbenzimidazole - metabolism Bisbenzimidazole - pharmacology Breast cancer Cancer therapies Caspase Caspase-3 Cell culture Cell cycle Cell Line, Tumor Cell morphology Coloring Agents - metabolism Coloring Agents - pharmacology Cytochrome Cytochrome c Cytology Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA microarrays Drug Antagonism Drug development Dyes Epidermal growth factor Gene expression Gene regulation Gene therapy Genes Humans Insulin-like growth factors Internal medicine Medicine Mesothelioma Mitochondria Molecular modelling Nucleic Acid Conformation - drug effects Permeability Pharmaceuticals Pharmacology Proteins Recombinant proteins Selectivity Signal transduction Signal Transduction - drug effects Signatures Studies Transcription Transcription (Genetics) Transcriptome - drug effects Translocation Tumors
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