PfMDR1: mechanisms of transport modulation by functional polymorphisms

ATP-Binding Cassette (ABC) transporters are efflux pumps frequently associated with multidrug resistance in many biological systems, including malaria. Antimalarial drug-resistance involves an ABC transporter, PfMDR1, a homologue of P-glycoprotein in humans. Twenty years of research have shown that...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e23875-e23875
Hauptverfasser:	Ferreira, Pedro Eduardo, Holmgren, Gabrielle, Veiga, Maria Isabel, Uhlén, Per, Kaneko, Akira, Gil, José Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Adenosine triphosphate Algorithms Allosteric properties Amino acids Analysis Antimalarials - metabolism Antimalarials - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Bacteria Binding Binding Sites Bioengineering Bioinformatics Biological Transport Biology Biophysics Biotechnology Chemotherapy Computer Science Computer simulation Conservation Crystallography Crystals Docking Drug resistance Drug Resistance - genetics Drugs Efflux Electric properties Enzymes Genetic aspects Glycoproteins Homology Humans Ligands Malaria Mammals Medicin och hälsovetenskap Medicine Microbial drug resistance Models, Molecular Modulation Multidrug resistance Mutation P-Glycoprotein Parasites Physiological aspects Physiological effects Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - metabolism Polymorphism, Single Nucleotide Protein Conformation Protein structure Proteins Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Residues Secondary structure Single nucleotide polymorphisms Single-nucleotide polymorphism Structural analysis Structural models Transport Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!