TIG3 tumor suppressor-dependent organelle redistribution and apoptosis in skin cancer cells

TIG3 is a tumor suppressor protein that limits keratinocyte survival during normal differentiation. It is also important in cancer, as TIG3 level is reduced in tumors and in skin cancer cell lines, suggesting that loss of expression may be required for cancer cell survival. An important goal is iden...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e23230-e23230
Hauptverfasser:	Scharadin, Tiffany M, Jiang, Haibing, Jans, Ralph, Rorke, Ellen A, Eckert, Richard L
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Actin Actin Cytoskeleton - metabolism Adenoviridae - genetics Apoptosis B cells BAX protein bcl-2-Associated X Protein - metabolism Bcl-x protein bcl-X Protein - metabolism Biochemistry Biology Cancer Caspase 3 - metabolism Caspase 9 - metabolism Cell Count Cell Cycle Cell Line, Tumor Cell Proliferation Cell Survival Centromere - metabolism Clustering Cyclin A Cyclin D1 Cyclin E Cyclins - metabolism Genetic Vectors - genetics Humans Immunoblotting Immunohistochemistry Infections Kinases Localization Medicine Microtubules - metabolism Molecular biology Molecular weight Organelles - metabolism Poly(ADP-ribose) Polymerases - metabolism Proteins Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Skin cancer Skin diseases Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Squamous cell carcinoma Survival Transfection Tumor cell lines Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors
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