Genetic variants in TGF-β pathway are associated with ovarian cancer risk

The transforming growth factor-β (TGF-β) signaling pathway is involved in a diverse array of cellular processes responsible for tumorigenesis. In this case-control study, we applied a pathway-based approach to evaluate single-nucleotide polymorphisms (SNPs) in the TGF-β signaling pathway as predicto...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25559-e25559
Hauptverfasser:	Yin, Jikai, Lu, Karen, Lin, Jie, Wu, Lei, Hildebrandt, Michelle A T, Chang, David W, Meyer, Larissa, Wu, Xifeng, Liang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biology Cancer Confidence intervals Female Genetic diversity Genetic Predisposition to Disease - genetics Genetic variance Genotype Genotypes Haplotypes Health risk assessment Health risks Humans Medicine Middle Aged Mutation Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Polymorphism, Single Nucleotide - genetics Population studies Risk analysis Risk factors Risk groups Signal transduction Signal Transduction - genetics Signal Transduction - physiology Signaling Single-nucleotide polymorphism Smad6 Protein - genetics Subgroups Transforming growth factor Transforming Growth Factor beta - genetics Transforming growth factor-b Tumorigenesis Womens health
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