A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis

Activation of the host antibacterial defenses by the toll-like receptors (TLR) also selectively activates energy-sensing and metabolic pathways, but the mechanisms are poorly understood. This includes the metabolic and mitochondrial biogenesis master co-activators, Ppargc1a (PGC-1α) and Ppargc1b (PG...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25249-e25249
Hauptverfasser:	Sweeney, Timothy E, Suliman, Hagir B, Hollingsworth, John W, Welty-Wolf, Karen E, Piantadosi, Claude A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adaptor Proteins, Vesicular Transport Animals Biological response modifiers Biology Biosynthesis Blotting, Western Chromatin Chromatin Immunoprecipitation Cytokines Deoxyribonucleic acid DNA DNA damage E coli Female Gene expression Gene regulation Genes Immune system Immunity Immunoprecipitation Infection Innate immunity Inoculation Interferon Interferon regulatory factor 3 Interferon regulatory factor 7 Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - metabolism Interferon Regulatory Factor-7 - genetics Interferon Regulatory Factor-7 - metabolism Kinases Liver Male Medicine Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Metabolic pathways Metabolism Mice Mice, Knockout Mitochondria MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism NF-kappa B - genetics NF-kappa B - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Promoter Regions, Genetic Proteins Receptors Receptors, Interleukin Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Rodents Sepsis Sepsis - genetics Sepsis - metabolism Sepsis - microbiology Signal transduction Signaling Staphylococcus aureus Staphylococcus aureus - pathogenicity TLR2 protein TLR4 protein Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors
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